Serum Irisin Levels and Its Relationship with Spasticity Severity in Chronic Stroke Patients

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dc.authoridKAYDOK, ERCAN/0000-0003-2262-7261
dc.contributor.authorKaydok, Ercan
dc.contributor.authorSari, Ismail
dc.contributor.authorErsan, Serpil
dc.contributor.authorKucuk, Esin Benli
dc.date.accessioned2024-11-07T13:24:14Z
dc.date.available2024-11-07T13:24:14Z
dc.date.issued2022
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractObjective Irisin is a myokine released from muscles by exercise and it has been shown to be a prognostic indicator in acute stroke patients. However, irisin's relationship with the chronic phase of stroke and spasticity has not been studied yet. We aimed to determine the serum level of irisin to examine its relationship with the functional status and severity of spasticity in patients with chronic stroke, and to compare these with healthy controls. Materials and Methods A total of 70 (35 chronic stroke and 35 control patients) patients were included in the study. The blood serum irisin levels of the patients and the controls were evaluated using enzyme-linked immunosorbent assay method, their functional status was evaluated with the modified Rankin scale (mRS), and spasticity severity using the modified Ashworth scale (MAS). Results The mean serum irisin levels of the stroke and the control groups were 6.20 +/- 2.2 and 5.45 +/- 2.3, respectively, and there was no statistically significant difference ( p > 0.05). No significant correlation was found between the serum level of irisin and the severity of spasticity and functional status, assessed by the mRS in stroke patients. Conclusion These results showed that irisin levels in chronic stroke patients were similar to controls, and there was no relationship between the severity of spasticity and functional status and irisin level.
dc.identifier.doi10.1055/s-0042-1747679
dc.identifier.endpage448
dc.identifier.issn0974-2727
dc.identifier.issn0974-7826
dc.identifier.issue4
dc.identifier.pmid36531544
dc.identifier.startpage443
dc.identifier.urihttps://doi.org/10.1055/s-0042-1747679
dc.identifier.urihttps://hdl.handle.net/11480/13996
dc.identifier.volume14
dc.identifier.wosWOS:000822606900001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherThieme Medical Publ Inc
dc.relation.ispartofJournal of Laboratory Physicians
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectIrisin
dc.subjectstroke
dc.subjectspasticity
dc.subjectfunctional outcomes
dc.titleSerum Irisin Levels and Its Relationship with Spasticity Severity in Chronic Stroke Patients
dc.typeArticle

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