Significant association between MDM2 T309G polymorphism and colorectal cancer

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dc.authoridbostanci, meric emre/0000-0002-0429-9834
dc.authoridSari, Ismail/0000-0003-3732-2102
dc.contributor.authorAtabey, Mustafa
dc.contributor.authorTas, Ayca
dc.contributor.authorSari, Ismail
dc.contributor.authorBostanci, Meric Emre
dc.contributor.authorTopcu, Omer
dc.contributor.authorSilig, Yavuz
dc.date.accessioned2024-11-07T13:34:39Z
dc.date.available2024-11-07T13:34:39Z
dc.date.issued2019
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractPurpose: The Murine double minute 2 (MDM2) gene plays a crucial role in regulating and suppressing the function of apoptotic pathway. We investigated the relationship between MDM2 gene SNP309 (T309G) (rs2279744) polymorphism and colorectal cancer (CRC) in a Turkish population. Methods: The polymorphism T309G (rs2279744) in the MDM2 gene was studied in patients with colorectal cancer (n=135) and healthy control subjects (n=145) using the polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) method The findings were evaluated using logistic regression and x(2) tests. Results: When CRC cases and controls were evaluated based on different habits and family cancer histories, a statistically significant relationship was found between CRC and alcohol consumption (x(2) =4.07, p=0.044). Cancer cases and controls had statistically significant different family histories of cancer (x(2) =6.82, p =0.009). There was also significant difference in TG genotype distribution in the MDM2 T309G polymorphism between those with and without cancer (OR=1.98, 95% CI =1.98-3.91, x(2) =4.00, p =0.045). Conclusions: The SNP309 polymorphism of the MDM2 gene is associated with increased CRC risk in the Turkish population.
dc.description.sponsorshipCumhuriyet University [CUBAP T-547]
dc.description.sponsorshipThis research was supported by Cumhuriyet University via research grants provided to the project CUBAP T-547.
dc.identifier.endpage1142
dc.identifier.issn1107-0625
dc.identifier.issn2241-6293
dc.identifier.issue3
dc.identifier.pmid31424672
dc.identifier.scopus2-s2.0-85067696702
dc.identifier.scopusqualityQ3
dc.identifier.startpage1137
dc.identifier.urihttps://hdl.handle.net/11480/16095
dc.identifier.volume24
dc.identifier.wosWOS:000471764000037
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherImprimatur Publications
dc.relation.ispartofJournal of Buon
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241106
dc.subjectcolorectal cancer
dc.subjectpolymorphism T309G (rs2279744)
dc.subjectMDM2 gene
dc.subjectTurkish population
dc.titleSignificant association between MDM2 T309G polymorphism and colorectal cancer
dc.typeArticle

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