The investigation of the antioxidative properties of the novel synthetic organoselenium compounds in some rat tissues

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dc.contributor.authorTalas, Zeliha Selamoglu
dc.contributor.authorOzdemir, Ilknur
dc.contributor.authorYilmaz, Ismet
dc.contributor.authorGok, Yetkin
dc.contributor.authorOrun, Ibrahim
dc.date.accessioned2019-08-01T13:38:39Z
dc.date.available2019-08-01T13:38:39Z
dc.date.issued2008
dc.departmentNiğde ÖHÜ
dc.description.abstractDMBA (7,12-dimethylbenz[a]anthracene) is a polycyclic aromatic hydrocarbon (PAH) known to cause tumors in rats. Selenium is an essential element with physiological nonenzymatic antioxidant properties. Because of the health problems induced by many environmental pollutants, many efforts have been undertaken in evaluating the relative antioxidant potential of selenium and synthetic organoselenium compounds. In this study, adult female Wistar rats were treated with DMBA and the novel organoselenium compounds (1-isopropyl-3-methylbenzimidazole-2-selenone [Sel] and 1,3di-p-methoxybenzylpyrimidine-2-selenone [Sell]) in the determined doses. The protective effects of novel synthetic organoselenium compounds (Sel and Sell) against DMBA-induced changes in superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) activities and total glutathione (GSH) and malonedialdehyde (MDA) levels of rat heart and brain were investigated. It was determined that Sel and Sell fully or partially restored enzyme activity. It was also found that lipid peroxidation was also decreased in Sel and Sell treated groups. Consequently, it was determined that novel synthetic organoselenium compounds (Sel and Sell) provided protection of antioxidant activity, and protection against lipid peroxidation measured as MDA in Sel and Sell treated groups was provided by novel synthesized organoselenium compounds. The ability of the organoselenium compounds to prevent oxidative damage induced by DMBA in rats was rationalized.
dc.identifier.doi10.3181/0707-RM-191
dc.identifier.endpage579
dc.identifier.issn1535-3702
dc.identifier.issn1535-3699
dc.identifier.issue5
dc.identifier.pmid18375834
dc.identifier.scopus2-s2.0-43249095483
dc.identifier.scopusqualityQ2
dc.identifier.startpage575
dc.identifier.urihttps://dx.doi.org/10.3181/0707-RM-191
dc.identifier.urihttps://hdl.handle.net/11480/5248
dc.identifier.volume233
dc.identifier.wosWOS:000255321300011
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor[0-Belirlenecek]
dc.language.isoen
dc.publisherSAGE PUBLICATIONS LTD
dc.relation.ispartofEXPERIMENTAL BIOLOGY AND MEDICINE
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectDMBA
dc.subjectbrain
dc.subjectheart
dc.subjectoxidative stress
dc.subjectrat
dc.subjectsynthetic organoselenium compounds
dc.titleThe investigation of the antioxidative properties of the novel synthetic organoselenium compounds in some rat tissues
dc.typeArticle

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