Association of IL-1Ra and IL-4 Gene VNTRs with Susceptibility to Prostate Cancer in Turkish Population

Basit Öğe Kaydı
dc.authoridBingol, Gunsel/0000-0001-9834-0019
dc.contributor.authorBingol, G.
dc.contributor.authorPolat, F.
dc.contributor.authorDiler, S. B.
dc.date.accessioned2024-11-07T13:32:45Z
dc.date.available2024-11-07T13:32:45Z
dc.date.issued2020
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractProstate cancer (PCa) is a very common type of cancer among men. It was revealed that Interleukin-4 (IL-4) and interleukin-1 receptor antagonist (IL-1Ra) genes had important functions such as development of prostate cells or regulating the inflammatory processes. The important role of cytokines in inflammatory mechanisms leads to the possibility that polymorphisms of these genes may contribute to the formation of prostate cancer. In this study, we aimed to investigate the association of variable number tandem repeat (VNTR) polymorphisms in the IL-1Ra and IL-4 genes with PCa in Turkish population. 70 prostate cancer patients and 110 healthy controls were involved in a case-control study. Genotype distributions and allele frequencies for the IL-1Ra intron 2 (rs2234663) and IL-4 intron 3 (rs79071878) VNTR polymorphisms were analyzed by using PCR technique. No statistically significant association was identified for both IL-1Ra intron 2 and IL-4 intron 3 polymorphisms between PCa patients and controls (P > 0.05). IL-1Ra intron 2 and IL-4 intron-3 VNTR polymorphisms were not found to be risk factors in prostate cancer and its development in Turkish population.
dc.identifier.doi10.3103/S0095452720050138
dc.identifier.endpage492
dc.identifier.issn0095-4527
dc.identifier.issn1934-9440
dc.identifier.issue5
dc.identifier.scopus2-s2.0-85092372132
dc.identifier.scopusqualityQ4
dc.identifier.startpage487
dc.identifier.urihttps://doi.org/10.3103/S0095452720050138
dc.identifier.urihttps://hdl.handle.net/11480/15588
dc.identifier.volume54
dc.identifier.wosWOS:000576813900013
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherAllerton Press Inc
dc.relation.ispartofCytology and Genetics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241106
dc.subjectprostate cancer
dc.subjectvariable number tandem repeats
dc.subjectinterleukin-1 receptor antagonist
dc.subjectinterleukin-4
dc.subjectpolymorphism
dc.titleAssociation of IL-1Ra and IL-4 Gene VNTRs with Susceptibility to Prostate Cancer in Turkish Population
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu