Bovine serum albumin-mediated synthesis and quorum sensing inhibitory properties of Ag-Ag2S nanoparticles

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dc.authoridBarsbay, Murat/0000-0003-0788-4446
dc.contributor.authorGhaffarlou, Mohammadreza
dc.contributor.authorIlk, Sedef
dc.contributor.authorRahimi, Hossein
dc.contributor.authorDanafar, Hossein
dc.contributor.authorBarsbay, Murat
dc.contributor.authorSharafi, Ali
dc.date.accessioned2024-11-07T13:35:01Z
dc.date.available2024-11-07T13:35:01Z
dc.date.issued2022
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractAim: Quorum sensing (QS) is a density-dependent chemical process of cell-to-cell communication in which certain signals are activated, leading to the coordination of pathogenic behaviors and the regulation of virulence in bacteria. Inhibition of QS can prevent biofilm formation and reduce virulence behaviors of bacteria. Herein, bovine serum albumin (BSA)-coated silver nanoparticles (NPs) (Ag-Ag2S@BSA NPs) were synthesized and studied as an anti-QS agent. Materials & methods: Ag-Ag2S NPs prepared through a BSA-mediated biomineralization process under ambient aqueous conditions and their physicochemical properties were characterized. The anti-QS activity of the resulting BSA-coated NPs (Ag-Ag2S@BSA NPs) was investigated for the first time. Results & conclusion: The result confirmed the potential of Ag-Ag2S@BSA NPs as novel and useful therapeutic tools for antibacterial purposes. Plain language summaryThe overuse of antibiotics has caused the development of drug-resistant strains of bacteria. Nowadays, drug resistance is one of the main challenges in the treatment and prevention of microbial diseases. In general, many bacterial species communicate with each other through a population-dependent mechanism called quorum sensing to control their physiological activities. Therefore, inhibiting the quorum sensing mechanism is an attractive alternative to antibiotics and also reduces the risk of drug resistance, and this can be achieved by nanoparticles (NPs). Among these nanostructures, Ag NPs have received particular attention due to their antimicrobial, antibiofilm, anticancer and antioxidant properties. Herein, we report a method that applies a BSA-guided green and one-pot approach for achieving Ag-Ag2S NPs as potential antibacterial agents.
dc.description.sponsorshipDeputy of Research of Zanjan University of Medical Sciences [A-12-848-28, IR.ZUMS.REC.1399.379]; International Atomic Energy Agency (IAEA); [23498]
dc.description.sponsorshipThis work was supported by the Deputy of Research of Zanjan University of Medical Sciences (Grant No: A-12-848-28, Ethical code: IR.ZUMS.REC.1399.379). M Barsbay acknowledges the financial support of the of the International Atomic Energy Agency (IAEA) under coordinated research project F22072 (IAEA research contract no. 23498) The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.
dc.identifier.doi10.2217/nnm-2022-0203
dc.identifier.endpage2155
dc.identifier.issn1743-5889
dc.identifier.issn1748-6963
dc.identifier.issue28
dc.identifier.pmid36853339
dc.identifier.scopus2-s2.0-85151168209
dc.identifier.scopusqualityQ1
dc.identifier.startpage2145
dc.identifier.urihttps://doi.org/10.2217/nnm-2022-0203
dc.identifier.urihttps://hdl.handle.net/11480/16285
dc.identifier.volume17
dc.identifier.wosWOS:000940536000001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofNanomedicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241106
dc.subjectAg-Ag2S nanoparticles
dc.subjectantibacterial
dc.subjectbiofilm
dc.subjectJanus NPs
dc.subjectquorum sensing
dc.subjectsilver
dc.titleBovine serum albumin-mediated synthesis and quorum sensing inhibitory properties of Ag-Ag2S nanoparticles
dc.typeArticle

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