Upper rim-functionalized calix[4]arene-based L-proline as organocatalyst for direct asymmetric aldol reactions in water and organic media
Küçük Resim Yok
Tarih
2014
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
PERGAMON-ELSEVIER SCIENCE LTD
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The synthesis of upper rim-functionalized calix[4]arene-based L-proline was described, and its catalytic efficiency as organocatalyst for the enantioselective aldol reaction in water was investigated. The results showed that the nature of the hydrophobic cavity of calixarene is critical for catalytic activity in water. The products of the reaction between various ketones and aldehydes with anti-configuration were obtained in high yields (up to 94%) with high diastereo- (up to 95:5 dr) and enantioselectivities (up to 80% ee). (C) 2014 Elsevier Ltd. All rights reserved.
Açıklama
Anahtar Kelimeler
Kaynak
TETRAHEDRON
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
70
Sayı
49
