Investigation of the correlation between ADMA levels and carotid artery intima-media thickness in rheumatoid arthritis patients [Romatoid artritli hastalarda ADMA düzeyleri ile karotid arter intima-media kali{dotless}nli{dotless}gi{dotless} arasi{dotless}ndaki i·lişkinin saptanmasi{dotless}]

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dc.contributor.authorKaraoglan B.
dc.contributor.authorÖztürk G.T.
dc.contributor.authorÖzdogan V.
dc.contributor.authorCumaoglu A.
dc.contributor.authorOktar S.
dc.contributor.authorTaş N.
dc.contributor.authorAricioglu A.
dc.date.accessioned2019-08-01T13:38:39Z
dc.date.available2019-08-01T13:38:39Z
dc.date.issued2011
dc.departmentNiğde ÖHÜ
dc.description.abstractObjective: Plasma asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthesis, is related to increased cardiovascular risks, endothelial dysfunction and atherosclerosis. Carotid artery intima-media thickness (IMT) is closely related to the risk of coronary artery disease. We aimed to investigate plasma ADMA levels and its relation to carotid IMT in patients with rheumatoid arthritis (RA). Materials and Methods: Eighteen Turkish patients with RA (16 females, mean age: 49.44±8.88 years) and 18 age- and gender-matched healthy controls (16 females, mean age: 46.28±4.97 years) were included in the study. Measurement of IMT was done by B-mode ultrasound. Plasma ADMA levels and carotid IMT of both sides were measured in all patients and healthy controls, and the means of the two groups were compared. The correlation between ADMA levels and carotid IMT was assessed in patients with RA. Results: Plasma ADMA levels were significantly higher in patients compared to healthy controls. Although the carotid IMT values were relatively higher in the patient group than in the control group, the difference was not statistically significant. There was no significant correlation between ADMA levels and carotid IMT values. Conclusion: Our findings support the notion that plasma ADMA levels are elevated in patients with RA. Despite lack of correlation between ADMA levels and IMT in our study, ADMA levels can be used to evaluate endothelial dysfunction. © Turkish Journal of Physical Medicine and Rehabilitation, Published by Galenos Publishing.
dc.identifier.doi10.4274/tftr.27879
dc.identifier.endpage118
dc.identifier.issn1302-0234
dc.identifier.issue3
dc.identifier.startpage114
dc.identifier.urihttps://dx.doi.org/10.4274/tftr.27879
dc.identifier.urihttps://hdl.handle.net/11480/925
dc.identifier.volume57
dc.institutionauthor[0-Belirlenecek]
dc.language.isoen
dc.relation.ispartofTurkiye Fiziksel Tip ve Rehabilitasyon Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectADMA
dc.subjectCarotid IMT
dc.subjectRheumatoid arthritis
dc.titleInvestigation of the correlation between ADMA levels and carotid artery intima-media thickness in rheumatoid arthritis patients [Romatoid artritli hastalarda ADMA düzeyleri ile karotid arter intima-media kali{dotless}nli{dotless}gi{dotless} arasi{dotless}ndaki i·lişkinin saptanmasi{dotless}]
dc.typeArticle

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