Antioxidant, antimicrobial and neuroprotective effects of Octaviania asterosperma in vitro

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dc.authoridSelamoglu, Zeliha/0000-0001-9056-6435
dc.authoridBraidy, Nady/0000-0002-0497-5572
dc.contributor.authorSevindik, Mustafa
dc.contributor.authorAkgul, Hasan
dc.contributor.authorSelamoglu, Zeliha
dc.contributor.authorBraidy, Nady
dc.date.accessioned2024-11-07T13:35:12Z
dc.date.available2024-11-07T13:35:12Z
dc.date.issued2021
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractOctaviania asterosperma (hypogeous Basidiomycota) We investigated the phenolic composition, and antioxidant, antimicrobial and antigenotoxic effects of methanol extracts of fruiting bodies from Octaviania asterosperma. The total phenolic content (ppm) of O. asterosperma was found to be catechin (54.73 +/- 4.68), epicatechin (123.90 +/- 8.52), caffeic acid (4.23 +/- 0.97), p-hydroxybenzoic acid (37.72 +/- 3.84), cinnamic acid (58.07 +/- 5.40), gallic acid (56.64 +/- 6.39), clorogenic acid (80.76 +/- 4.92) and coumaric acid (2.45 +/- 0.15). The total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI) were 3.410 +/- 0.099 mmol/L, 7.548 +/- 0.147 mu mol/L and 0.221 +/- 0.005 respectively. O. asterosperma showed some promising antimicrobial activity. The extract showed no genotoxic potential and attenuated hydrogen peroxide (H2O2)-induced oxidative DNA damage in neurons. Pre-treatment with O. asterosperma maintained mitochondrial function, reduced expression levels of cleaved-caspase-3 and apoptosis-inducing factor (AIF) when HT22 cells were exposed to pathophysiological concentrations of GLU (25 mM) and modulated protein kinase B (Akt), the mammalian target of rapamycin (mTOR), and the phosphotase and tensin homolog on chromosome ten (PTEN). O. asterosperma is an important food for the treatment or management of neurodegenerative disorders due to its phenolic content and potent antioxidant and anti-excitotoxic effects.
dc.description.sponsorshipOsmaniye Korkut Ata University, Central Research Laboratory
dc.description.sponsorshipWe thank Osmaniye Korkut Ata University, Central Research Laboratory for their support. We would like to express our gratitude to Dr. Omer F. Colak and Dr. Ilgaz AKATA for their contribution to the present study.
dc.identifier.doi10.1080/21501203.2020.1816584
dc.identifier.endpage138
dc.identifier.issn2150-1203
dc.identifier.issn2150-1211
dc.identifier.issue2
dc.identifier.pmid34035978
dc.identifier.scopus2-s2.0-85097065532
dc.identifier.scopusqualityQ1
dc.identifier.startpage128
dc.identifier.urihttps://doi.org/10.1080/21501203.2020.1816584
dc.identifier.urihttps://hdl.handle.net/11480/16367
dc.identifier.volume12
dc.identifier.wosWOS:000596348000001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofMycology-An International Journal on Fungal Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectOctaviania asterosperma
dc.subjectphenolic compounds
dc.subjectantioxidant
dc.subjectantimicrobial
dc.subjectoxidant
dc.subjectL-glutamate
dc.titleAntioxidant, antimicrobial and neuroprotective effects of Octaviania asterosperma in vitro
dc.typeArticle

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