Caries-related salivary parameters and oral microbial flora in patients with type 1 diabetes: A meta-analysis

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dc.authoridHatipoglu, Omer/0000-0002-4628-8551
dc.contributor.authorHatipoglu, Omer
dc.contributor.authorOnsuren, Asli Sogukpinar
dc.contributor.authorHatipoglu, Fatma Pertek
dc.contributor.authorKurt, Ayca
dc.date.accessioned2024-11-07T13:32:56Z
dc.date.available2024-11-07T13:32:56Z
dc.date.issued2022
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractObjectives This study aimed to conduct a meta-analysis by synthesising the outcomes of studies that investigated the relationship between type 1 diabetes (T1D) and salivary flow rate (SFR), salivary pH (SpH), salivary buffer capacity (SBC), streptococcus Mutans (SM), and lactobacillus (LB) counts. Material and Methods The PRISMA statement guide was followed for the meta-analysis. Electronic databases were searched, and study selection and data collection processes were performed. The risks of bias in individual studies and across studies were assessed. Mean differences (MD) and Odds Ratio (OR) were used to measure the effect estimates in the comparisons. Results 29 studies were included in the qualitative and quantitative syntheses. Significantly higher SFR (MD = -0.22, CI: -0.26, -0.18; p < 0.001) and SpH (MD = -0.59, CI: -0.81, -0.36; p < 0.001) were observed in the healthy individuals than T1D individuals. No significant difference was observed among groups in terms of SBC (MD = 0.10, CI: -0.46,0.66; p = 0.73). An increased odds ratio of SM counts were observed regarding the T1D (OR = 3.09, 95% CI: 1.16, 8.20; p = 0.02). No association was found between LB counts and T1D (OR = 2.15, 95% CI: 0.38, 11.98; p = 0.38). Conclusions Subjects with T1D have a significantly lesser SFR and SpH than healthy individuals. But no significant difference is available in terms of SBC. Lower SM counts were observed in individuals with T1D, while no association was observed regarding LB counts. The tendency to dental caries is more likely in subjects with T1D due to lower SFR, SpH, and higher SM.
dc.identifier.doi10.1002/dmrr.3527
dc.identifier.issn1520-7552
dc.identifier.issn1520-7560
dc.identifier.issue5
dc.identifier.pmid35289060
dc.identifier.scopus2-s2.0-85127269849
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1002/dmrr.3527
dc.identifier.urihttps://hdl.handle.net/11480/15693
dc.identifier.volume38
dc.identifier.wosWOS:000773525900001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofDiabetes-Metabolism Research and Reviews
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241106
dc.subjectsalivary buffer capacity
dc.subjectsalivary flow rate
dc.subjectsalivary pH
dc.subjecttype1 diabetes
dc.titleCaries-related salivary parameters and oral microbial flora in patients with type 1 diabetes: A meta-analysis
dc.typeArticle

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