Association of MYNN, TERT and TERC Gene Polymorphisms with Prostate Cancer in Turkish Population

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dc.authoridBingol, Gunsel/0000-0001-9834-0019
dc.contributor.authorPolat, F.
dc.contributor.authorDiler, S. B.
dc.contributor.authorBingol, G.
dc.date.accessioned2024-11-07T13:32:55Z
dc.date.available2024-11-07T13:32:55Z
dc.date.issued2020
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractThis study aims to determine whether there is any relationship between prostate cancer development and MYNN rs10 936 599, TERC rs2 293 607 and hTERT MNS16A polymorphisms in Turkish population. The research was comprised of 77 individuals with prostate cancer and 116 healthy individuals without history of cancer. Genotyping analysis was performed using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) methods. The results obtained were evaluated using the chi-square test and unconditional logistic regression analysis. In the study, the GG genotype of TERC rs2293607 polymorphism, the VNTR-243/243 genotype of TERT MNS16A polymorphism, and allele 243 were found to be statistically significant between the patient and control groups (ORc = 3.250, 95% CI = 1.176-8.980, p(c) = 0.023; ORc = 3.09, 95% CI = 1.238-7.717, p(c) = 0.016; OR = 0.638, 95% CI = 0.416-0.978, p = 0.038). On the other hand, there was no significant relationship between MYNN rs109365999 polymorphism and prostate cancer in Turkish population. In conclusion, the obtained data show that the TERC rs2293607 and TERT MNS16A VNTR-243/243 polymorphisms might be potential risk factors for the development of prostate cancer in Turkish population and might be suggested as prognostic markers.
dc.description.sponsorshipKocaeli University [2014-045]
dc.description.sponsorshipL We would like to thank to Scientific Research Project Unit of Kocaeli University (Project no. 2014-045).
dc.identifier.doi10.3103/S0095452720060080
dc.identifier.endpage581
dc.identifier.issn0095-4527
dc.identifier.issn1934-9440
dc.identifier.issue6
dc.identifier.scopus2-s2.0-85099411581
dc.identifier.scopusqualityQ4
dc.identifier.startpage574
dc.identifier.urihttps://doi.org/10.3103/S0095452720060080
dc.identifier.urihttps://hdl.handle.net/11480/15659
dc.identifier.volume54
dc.identifier.wosWOS:000608056500009
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherPleiades Publishing Inc
dc.relation.ispartofCytology and Genetics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241106
dc.subjectMYNN
dc.subjectTERT
dc.subjectTERC
dc.subjectprostate cancer
dc.subjectTurkish population
dc.titleAssociation of MYNN, TERT and TERC Gene Polymorphisms with Prostate Cancer in Turkish Population
dc.typeArticle

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