Potential Anticancer Properties and Mechanisms of Action of Formononetin

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dc.authoridHUSSAIN, Ghulam/0000-0001-9090-7789
dc.authoridSelamoglu, Zeliha/0000-0001-9056-6435
dc.authoridJiang, Dongjun/0000-0001-6198-4531
dc.authoridTahir, Muhammad Mateen/0000-0003-0118-4836
dc.authoridRasul, Azhar/0000-0001-9669-7364
dc.contributor.authorJiang, Dongjun
dc.contributor.authorRasul, Azhar
dc.contributor.authorBatool, Rabia
dc.contributor.authorSarfraz, Iqra
dc.contributor.authorHussain, Ghulam
dc.contributor.authorTahir, Muhammad Mateen
dc.contributor.authorQin, Tian
dc.date.accessioned2024-11-07T13:34:54Z
dc.date.available2024-11-07T13:34:54Z
dc.date.issued2019
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractNature, a vast reservoir of pharmacologically active molecules, has been most promising source of drug leads for the cure of various pathological conditions. Formononetin is one of the bioactive isoflavones isolated from different plants mainly from Trifolium pratense, Glycine max, Sophora flavescens, Pycnanthus angolensis, and Astragalus membranaceus. Formononetin has been well-documented for its anti-inflammatory, anticancer, and antioxidant properties. Recently anticancer activity of formononetin is widely studied. This review aims to highlight the pharmacological potential of formononetin, thus providing an insight of its status in cancer therapeutics. Formononetin fights progression of cancer via inducing apoptosis, arresting cell cycle, and halting metastasis via targeting various pathways which are generally modulated in several cancers. Although reported data acclaims various biological properties of formononetin, further experimentation on mechanism of its action, medicinal chemistry studies, and preclinical investigations are surely needed to figure out full array of its pharmacological and biological potential
dc.description.sponsorshipMinistry of Science and Technology, China [2016YFE0128500]; National Natural Science Foundation of China [31870758]; Jilin Provincial Science and Technology Department [20180414057GH, 20170204009YY]; Changchun Science & Technology Department, China [17YJ006, 17YJ001]; University S & T Innovation Platform of Jilin Province for Economic Fungi [2014B-1]; Program for Introducing Talents to Universities [B07017]; Nagai Foundation Tokyo, Japan [NFT-R-2018]; TWAS-COMSTECH Research Grant [17-180 RG/PHA/AS_C]; NRPU Research Grants [8381/Punjab/NRPU/RD/HEC/2017, 8382/Punjab/NRPU/RD/HEC/2017]
dc.description.sponsorshipThis study was supported by Ministry of Science and Technology, China (no. 2016YFE0128500), National Natural Science Foundation of China (no. 31870758), Jilin Provincial Science and Technology Department (20180414057GH, 20170204009YY), Changchun Science & Technology Department, China (17YJ006; 17YJ001), University S & T Innovation Platform of Jilin Province for Economic Fungi (#2014B-1), the Program for Introducing Talents to Universities (no. B07017), The Nagai Foundation Tokyo, Japan (NFT-R-2018), TWAS-COMSTECH Research Grant (no._17-180 RG/PHA/AS_C), and NRPU Research Grants (8381/Punjab/NRPU/R&D/HEC/2017, 8382/Punjab/NRPU/R&D/HEC/2017). The authors would also like to thank Higher Education Commission (HEC), Pakistan, for providing access to related papers from various journals.
dc.identifier.doi10.1155/2019/5854315
dc.identifier.issn2314-6133
dc.identifier.issn2314-6141
dc.identifier.pmid31467899
dc.identifier.scopus2-s2.0-85071174522
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1155/2019/5854315
dc.identifier.urihttps://hdl.handle.net/11480/16239
dc.identifier.volume2019
dc.identifier.wosWOS:000481932200001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherHindawi Ltd
dc.relation.ispartofBiomed Research International
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectCell-Cycle Arrest
dc.subjectEstrogen-Receptor-Alpha
dc.subjectProstate-Cancer Cells
dc.subjectHuman Breast-Cancer
dc.subjectIn-Vitro
dc.subjectAstragalus-Membranaceus
dc.subjectNatural-Products
dc.subjectDown-Regulation
dc.subjectPromotes Proliferation
dc.subjectAntitumor-Activity
dc.titlePotential Anticancer Properties and Mechanisms of Action of Formononetin
dc.typeReview Article

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