Effects of the maternal gut microbiome and gut-placental axis on melatonin efficacy in alleviating cadmium-induced fetal growth restriction

Basit Öğe Kaydı
dc.authoridElsabagh, Mabrouk/0000-0002-0596-6547
dc.authoridMa, Yi/0000-0002-3781-314X
dc.contributor.authorZhang, Hao
dc.contributor.authorLiu, Xiaoyun
dc.contributor.authorZheng, Yi
dc.contributor.authorZha, Xia
dc.contributor.authorElsabagh, Mabrouk
dc.contributor.authorZhang, Ying
dc.contributor.authorMa, Yi
dc.date.accessioned2024-11-07T13:35:12Z
dc.date.available2024-11-07T13:35:12Z
dc.date.issued2022
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractCadmium (Cd) is a major environmental stressor that induces fetal growth restriction (FGR). Also, changes in gut microbiome diversity-which can be modulated positively by melatonin (Mel) have implications on fetal development and placental functions. Therefore, this study aimed to explore whether the role of Mel in counteracting the Cd-induced FGR by regulating placental barrier injury, endoplasmic reticulum stress (ERS) and mitophagy in pregnant mice is mediated-in part-via the gut microbiota modulations. Pregnant mice were intraperitoneally injected with CdCl2 (5 mg/kg) and Mel (5 mg/kg) once daily, respectively, at the same time from gestational day (GD) 8 to GD18, and then the maternal colon and placental tissues were collected for detection. To investigate the inner relationship between intestinal flora and the protection of Mel on FGR caused by Cd, gut microbiota transplantation (GMT) was carried out from GD0 to GD18 after the removal of intestinal microbiota by antibiotics. Results indicated that Mel relieved barrier injury, ERS and mitophagy in the placenta, and reversed the maternal gut microbiota dysbiosis. The GMT approach suggested a role of intestinal microbiota in placental barrier injury, ERS and mitophagy induced by Cd. Overall, the results highlighted that the intestinal microbiota and gut-placental axis play a central role in the protective effect of Mel against Cd-induced FGR.
dc.description.sponsorshipNational Natural Science Foundation of China [31902180]; Top Talents Award Plan of Yangzhou University (2020); Cyanine Project Yangzhou University (2020)
dc.description.sponsorshipThe research was supported by the fund for the National Natural Science Foundation of China (Grant number 31902180) , the Top Talents Award Plan of Yangzhou University (2020) , and the Cyanine Project Yangzhou University (2020) . The authors thank all the members Hong Rong Wang;s laboratory for their contribution to sample determination.
dc.identifier.doi10.1016/j.ecoenv.2022.113550
dc.identifier.issn0147-6513
dc.identifier.issn1090-2414
dc.identifier.pmid35487173
dc.identifier.scopus2-s2.0-85129972301
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.ecoenv.2022.113550
dc.identifier.urihttps://hdl.handle.net/11480/16360
dc.identifier.volume237
dc.identifier.wosWOS:000799007600007
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAcademic Press Inc Elsevier Science
dc.relation.ispartofEcotoxicology and Environmental Safety
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectCadmium
dc.subjectFetal growth restriction
dc.subjectMelatonin
dc.subjectGut microbiota
dc.subjectGut-placenta axis
dc.titleEffects of the maternal gut microbiome and gut-placental axis on melatonin efficacy in alleviating cadmium-induced fetal growth restriction
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu