Impact of Varicocele Repair on Assisted Reproductive Technique Outcomes in Infertile Men: A Systematic Review and Meta-Analysis

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dc.authoridHarraz, Ahmed/0000-0002-8902-517X
dc.authoridKOTHARI, PRIYANK/0000-0002-3940-952X
dc.authoridCrafa, Andrea/0000-0002-8311-9095
dc.authoridKumar, Naveen/0000-0001-6176-6913
dc.authoridBOCU, Kadir/0000-0003-4323-4037
dc.authoridpalani, Ayad/0000-0001-7806-9903
dc.authoridSalvio, Gianmaria/0000-0001-9290-5699
dc.contributor.authorPalani, Ayad
dc.contributor.authorCannarella, Rossella
dc.contributor.authorSaleh, Ramadan
dc.contributor.authorSalvio, Gianmaria
dc.contributor.authorHarraz, Ahmed M.
dc.contributor.authorCrafa, Andrea
dc.contributor.authorBahar, Fahmi
dc.date.accessioned2024-11-07T13:35:30Z
dc.date.available2024-11-07T13:35:30Z
dc.date.issued2024
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractPurpose: In this systematic review and meta-analysis, we investigated assisted reproductive technology (ART) success in in- fertile men with clinical varicocele and abnormal semen parameters who underwent varicocele repair (VR) before the ART procedure as compared to those who did not. Materials and Methods: A comprehensive search of the Scopus, PubMed, Embase, and Cochrane Library databases was con- ducted using a specific query string to identify studies examining the impact of VR on ART outcomes, including fertilization rate, clinical pregnancy, pregnancy loss, and live-birth rate, until October 2023. Outcomes were analyzed based on the type of ART. Studies on VR in infertile men with non-obstructive azoospermia and those who underwent ART only due to female factor infertility were excluded from the study. Results: Out of 1,554 articles reviewed, only 9 met the inclusion criteria for the study. All the included articles were obser- vational studies. The variability in study quality in the included literature resulted in a moderate overall risk of bias. Data analysis showed that for intrauterine insemination, there was no difference in the clinical pregnancy rate (odds ratio [OR] 1.01, 95% confidence interval [CI]: 0.42, 2.45; p=0.97). However, for intracytoplasmic sperm injection (ICSI), men with VR showed a significant improvement in fertilization rate (mean difference 10.9, 95% CI: 5.94, 15.89; p<0.01), clinical pregnan- cy rate (OR 1.38, 95% CI: 1.07, 1.78; p=0.01) and live-birth rate (OR 2.07, 95% CI: 1.45, 2.97; p<0.01), compared to men who did not undergo VR. Conclusions: The findings of this systematic review and meta-analysis suggest that VR has a positive impact on pregnancy and live birth rates after ICSI. However, biases like small sample sizes and heterogeneous populations highlight the need for larger, well-designed prospective studies to validate these findings.
dc.description.sponsorshipThe findings of our SRMA support a positive effect of VR before ICSI on pregnancy and live birth rates. Well-designed RCTs are needed to validate these re-sults and further elucidate the impact of VR on ART outcomes across different patient populations.
dc.identifier.doi10.5534/wjmh.240132
dc.identifier.issn2287-4208
dc.identifier.issn2287-4690
dc.identifier.pmid39344117
dc.identifier.urihttps://doi.org/10.5534/wjmh.240132
dc.identifier.urihttps://hdl.handle.net/11480/16545
dc.identifier.wosWOS:001334458200001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherKorean Soc Sexual Medicine & Andrology
dc.relation.ispartofWorld Journal of Mens Health
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectInfertility, male
dc.subjectInsemination, artificial
dc.subjectReproductive techniques, assisted
dc.subjectSperm injections, intracytoplasmic
dc.subjectVaricocele
dc.titleImpact of Varicocele Repair on Assisted Reproductive Technique Outcomes in Infertile Men: A Systematic Review and Meta-Analysis
dc.typeReview Article

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