Regenerative Therapy in Erectile Dysfunction: A Survey on Current Global Practice Trends and GAF Expert Recommendations

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dc.authoridArafa, Mohamed/0000-0003-0107-8857
dc.authoridBusetto, Gian Maria/0000-0002-7291-0316
dc.authoridRambhatla, Amarnath/0000-0002-1383-6670
dc.authoridAlnajjar, Hussain/0000-0001-6364-0310
dc.authoridThomas, Charalampos/0000-0003-0139-2221
dc.authoridToprak, Tuncay/0000-0003-1348-5273
dc.authoridMostafa, Taymour/0000-0003-3627-0662
dc.contributor.authorAl Hashimi, Manaf
dc.contributor.authorPinggera, Germar-M
dc.contributor.authorMostafa, Taymour
dc.contributor.authorRambhatla, Amarnath
dc.contributor.authorHamoda, Taha
dc.contributor.authorShah, Rupin
dc.contributor.authorChung, Eric
dc.date.accessioned2024-11-07T13:35:37Z
dc.date.available2024-11-07T13:35:37Z
dc.date.issued2024
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractPurpose: This study aimed to examine current global practices in regenerative therapy (RT) for erectile dysfunction (ED) and to establish expert recommendations for its use, addressing the current lack of solid evidence and standardized guidelines. Materials and Methods: A 39-question survey was developed by senior Global Andrology Forum (GAF) experts to comprehensively cover clinical aspects of RT. This was distributed globally via a secure online Google Form to ED specialists through the GAF website, international professional societies, and social media, the responses were analyzed and presented for frequencies as percentages. Consensus on expert recommendations for RT use was achieved using the Delphi method. Results: Out of 479 respondents from 62 countries, a third reported using RT for ED. The most popular treatment was low-intensity shock wave therapy (54.6%), followed by platelet-rich plasma (24.5%) and their combination (14.7%), with stem cell therapy being the least used (3.7%). The primary indication for RT was the refractory or adverse effects of PDE5 inhibitors, with the best effectiveness reported in middle-aged and mild-to-moderate ED patients. Respondents were confident about its overall safety, with a significant number expressing interest in RT's future use, despite pending guidelines support. Conclusions: This inaugural global survey reveals a growing use of RT in ED treatment, showcasing its diverse clinical applications and potential for future widespread adoption. However, the lack of comprehensive evidence and clear guidelines requires further research to standardize RT practices in ED treatment.
dc.description.sponsorshipThe authors are thankful to the following societies for pro- moting the online survey through the efforts of their members, Arab Association of Urology, Arab British Urological Society, Austrian Society of Urology, Egyptian Urological Association and Egyptian Society of Andrology, Indonesian Urological Society, Saudi Urological Society and Turkish Urology Associa- tion. Daniela Delgadillo (Administrative Research Coordinator, Global Andrology Foundation) provided support for manuscript submission.
dc.identifier.doi10.5534/wjmh.240086
dc.identifier.issn2287-4208
dc.identifier.issn2287-4690
dc.identifier.pmid39028131
dc.identifier.urihttps://doi.org/10.5534/wjmh.240086
dc.identifier.urihttps://hdl.handle.net/11480/16593
dc.identifier.wosWOS:001272309100001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherKorean Soc Sexual Medicine & Andrology
dc.relation.ispartofWorld Journal of Mens Health
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectErectile dysfunction
dc.subjectExtracorporeal shockwave therapy
dc.subjectPlatelet-rich plasma
dc.subjectRegenerative medicine
dc.subjectStem cells
dc.subjectSurveys and questionnaires
dc.titleRegenerative Therapy in Erectile Dysfunction: A Survey on Current Global Practice Trends and GAF Expert Recommendations
dc.typeArticle

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