The Protective Effects of Curcumin on Organophosphate Insecticide Chlorpyrifos-Induced Oxidative Stress and DNA Damage in Oncorhynchus mykiss

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dc.authoridkoyuncu, ismail/0000-0002-9469-4757
dc.authoridARAL, FARUK/0000-0003-2297-6509
dc.authoridDogu, Zafer/0000-0002-5428-8340
dc.authoridSAHINOZ, ERDINC/0000-0003-0646-6939
dc.contributor.authorSahinoz, Erdinc
dc.contributor.authorAral, Faruk
dc.contributor.authorDogu, Zafer
dc.contributor.authorKoyuncu, Ismail
dc.contributor.authorYuksekdag, Ozgur
dc.date.accessioned2024-11-07T13:32:02Z
dc.date.available2024-11-07T13:32:02Z
dc.date.issued2020
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractThe aim of this study was to determine the levels of enzymatic and nonenzymatic antioxidants and DNA damage in blood of rainbow trout (Oncorhynchus mykiss) exposed to chlorpyrifos (CPF) and the protective effects of curcumin (CUR) on CPF-induced oxidative stress and DNA damage. For this purpose, 0.5% and 1.0% of CUR was administered via the intraperitoneal route for 45 days during exposure to water containing 0.040 mg/L CPF in rainbow trout. We observed a significant decrease in total peroxide (TP), glutathione (GSH), GSH peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT), paraoxonase (PON), and ferric ion reducing antioxidant power (FRAP) levels, whereas there was a significant increase in TP level in CPF-exposed rainbow trout (P<0.05). Antioxidants, depending on the dose, had relatively modest to significant effects on CPF-induced oxidative stress. Low doses of CUR also significantly increased serum FRAP levels in rainbow trout exposed to CPF (P<0.05). We observed increased comet assay levels in blood, predominantly in rainbow trout exposed to CPF (P<0.05). The amount of DNA damage induced by CPF exposure was more than that in the control. Overall, this study shows that CUR, depending on the dose, may modify CPF toxicity to a moderate or high degree in rainbow trout.
dc.description.sponsorshipHarran University Scientific Research Commission (HUBAK) [K-16213]
dc.description.sponsorshipWe declare that we have no conflicts of interest. This work was supported by the [Harran University Scientific Research Commission (HUBAK)] under Grant [number K-16213].
dc.identifier.doi10.4194/1303-2712-v20_3_03
dc.identifier.endpage195
dc.identifier.issn1303-2712
dc.identifier.issn2149-181X
dc.identifier.issue3
dc.identifier.scopus2-s2.0-85073467928
dc.identifier.scopusqualityQ3
dc.identifier.startpage185
dc.identifier.urihttps://doi.org/10.4194/1303-2712-v20_3_03
dc.identifier.urihttps://hdl.handle.net/11480/15170
dc.identifier.volume20
dc.identifier.wosWOS:000486924400003
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherCentral Fisheries Research Inst
dc.relation.ispartofTurkish Journal of Fisheries and Aquatic Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectPesticide
dc.subjectChlorpyrifos
dc.subjectCurcumin
dc.subjectOxidative Stress
dc.subjectDNA Damage
dc.titleThe Protective Effects of Curcumin on Organophosphate Insecticide Chlorpyrifos-Induced Oxidative Stress and DNA Damage in Oncorhynchus mykiss
dc.typeArticle

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