Serum myeloperoxidase, paraoxonase, and plasma asprosin concentrations in patients with acute myocardial infarction

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dc.authoridDOLANBAY, TURGUT/0000-0002-4092-1192
dc.contributor.authorCiftci, Handan
dc.contributor.authorGul, Huseyin Fatih
dc.contributor.authorSahin, Levent
dc.contributor.authorDolanbay, Turgut
dc.contributor.authorCanacik, Omer
dc.contributor.authorKarsli, Emre
dc.contributor.authorErcin, Dogan
dc.date.accessioned2024-11-07T13:35:24Z
dc.date.available2024-11-07T13:35:24Z
dc.date.issued2024
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractIntroduction: The objective of this study was to evaluate the usefulness of the serum biomarkers myeloperoxidase (MPO), paraoxonase (PON), and plasma asprosin in acute myocardial infarction (AMI) diagnosis and assess their compatibility with routinely screened cardiac biomarkers. Methods: This study was conducted using a prospective cross-sectional design and included 90 patients, consisting of 60 patients diagnosed with AMI (30 with ST-segment elevation and 30 with non-ST-segment elevation on ECG) and 30 controls (without a diagnosis of AMI). Changes in the levels of cardiac biomarkers (Hs-cTnI, CK, CK-MB), lipid profile (TC, TG, LDL, HDL), MPO, PON, asprosin, and routine biochemical parameters of patients were evaluated. Furthermore, receiver operating characteristic curve analysis revealed the diagnostic value of Hs-cTnI, MPO, PON, and asprosin in predicting AMI. Binary logistic regression analysis of cardiac marker concentrations was used to predict the presence of AMI. In contrast, multinomial logistic regression analysis was conducted to predict the type of AMI and the control group. Results: The median levels of MPO and plasma asprosin were found to be higher in the patient group (3.22 [interquartile range {IQR}: 2.4-4.4] ng/ml and 10.84 [IQR: 8.8-17.8] ng/ml, respectively) than in the control group (2.49 [IQR: 1.9-2.9] ng/ml and 4.82 [IQR: 4.6-8.0] ng/ ml, respectively) (p = 0.001 and p < 0.001, respectively). The median levels of PON were 8.94 (IQR: 7.6-10.4) ng/ml in the patient group and 10.44 (IQR: 9.1-20.0) ng/ml in the control group (p < 0.001). In the binary logistic regression model, compared with the control group, a 1 ng/ml increase in MPO level increased the odds of having AMI by 3.61 (p = 0.041, 95% CI: 1.055-12.397), whereas a 1 ng/ml increase in asprosin level increased the odds of having AMI by 2.33 (p < 0.001, 95% CI: 1.479-3.683). In the multinominal logistic regression model, compared with the control group, a 1 ng/ml increase in the MPO level increased the odds of having NSTEMI by 4.14 (p = 0.025, 95% CI: 1.195-14.350), whereas a 1 ng/ml increase in asprosin concentrations increased the odds of having NSTEMI by 2.35 (p < 0.001, 95% CI: 1.494-3.721). Conclusion: Herein, MPO and asprosin concentrations increased with Hs-cTnI, and a decrease in PON concentration indicated that oxidant-antioxidant parameters and adipokines were related to AMI pathogenesis.
dc.description.sponsorshipScientific Research Projects Coordinatorship of Kafkas University,Turkey [2021-TS-09]
dc.description.sponsorshipThis study was financially supported by the Scientific Research Projects Coordinatorship of Kafkas University,Turkey, under the project number 2021-TS-09.
dc.identifier.doi10.1016/j.heliyon.2024.e29465
dc.identifier.issn2405-8440
dc.identifier.issue8
dc.identifier.pmid38665586
dc.identifier.scopus2-s2.0-85190533008
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.heliyon.2024.e29465
dc.identifier.urihttps://hdl.handle.net/11480/16473
dc.identifier.volume10
dc.identifier.wosWOS:001232676700001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherCell Press
dc.relation.ispartofHeliyon
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectAcute myocardial infarction
dc.subjectHs-cTnI
dc.subjectMyeloperoxidase
dc.subjectParaoxonase
dc.subjectAsprosin
dc.titleSerum myeloperoxidase, paraoxonase, and plasma asprosin concentrations in patients with acute myocardial infarction
dc.typeArticle

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