Nutrition and nutraceuticals for brain cancer

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dc.contributor.authorSadiqa, Ayesha
dc.contributor.authorRasul, Azhar
dc.contributor.authorHussain, Ghulam
dc.contributor.authorShah, Muhammad Ajmal
dc.contributor.authorSarfraz, Iqra
dc.contributor.authorRiaz, Ammara
dc.contributor.authorSarfraz, Ayesha
dc.date.accessioned2024-11-07T10:40:29Z
dc.date.available2024-11-07T10:40:29Z
dc.date.issued2021
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractBrain cancers are highly lethal and fatal human cancers due to various hurdles imposed by the brain's physiology and anatomy on therapeutic implications. Higher relapse rates and poor prognosis in brain cancers complicate the situation, leading to high mortalities. Therefore, it is the need of the hour to develop efficient therapeutic strategies against brain cancers. The exploitation of nutraceuticals is an emerging approach for the cure of cancers due to their safety, efficacy, and cost-effectiveness. This chapter focuses on the significance and mechanism of anti-brain cancer nutraceuticals such as juglone, formononetin, eugenol, curcumin, and biochanin. The anti-brain cancer activity of nutraceuticals is governed by the modulation of various cell signaling molecules such as apoptosis-related factors (caspase-3, caspase-9, Bax, Bid, Reactive oxygen species), cell cycle regulators (Cyclin D1, p53), protein kinases (FAK, p-ERK, p38 MAPK), enzymes (MMP-2, MMP-9), transcriptional factors (c-myc, Wnt, ?-catenin), and cytokines (TGF-?). The reported data recommend multitarget activity of nutraceuticals which might play an essential role in developing nutraceuticals to novel pharmacological drugs shortly. © 2021 Nova Science Publishers, Inc. All rights reserved.
dc.identifier.endpage348
dc.identifier.isbn978-153619608-5978-153619463-0
dc.identifier.scopus2-s2.0-85109625888
dc.identifier.scopusqualityN/A
dc.identifier.startpage327
dc.identifier.urihttps://hdl.handle.net/11480/11710
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherNova Science Publishers, Inc.
dc.relation.ispartofBioactive Nutraceuticals for Brain Disorders
dc.relation.publicationcategoryKitap Bölümü - Uluslararası
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241106
dc.subjectAnti-cancer
dc.subjectBrain cancer
dc.subjectEugenol
dc.subjectFormononetin
dc.subjectGlioblastoma
dc.subjectJuglone
dc.subjectNutraceuticals
dc.titleNutrition and nutraceuticals for brain cancer
dc.typeBook Chapter

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