Antioxidative effects of novel synthetic organoselenium compound in rat lung and kidney

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dc.contributor.authorTalas, Zeliha Selamoglu
dc.contributor.authorOzdemir, Ilknur
dc.contributor.authorYilmaz, Ismet
dc.contributor.authorGok, Yetkin
dc.date.accessioned2019-08-01T13:38:39Z
dc.date.available2019-08-01T13:38:39Z
dc.date.issued2009
dc.departmentNiğde ÖHÜ
dc.description.abstractThe effects of environmental chemicals, drugs, and physical agents on the developing lung and kidney are influenced by the state of development and maturation. Selenium is an essential element with physiological nonenzymatic antioxidant properties. Therefore, we undertook the present study to evaluate the antioxidant potential of the novel synthetic organoselenium compounds (Se I and Se II). In this study, adult female Wistar rats were treated with DMBA and the novel organoselenium compounds [1-isopropyl-3-methylbenzimidazole-2-selenone (Se I) and 1,3-di-p-methoxybenzylpyrimidine-2-selenone (Se II)] in the determined doses. The protective effects of novel synthetic organoselenium compounds (Se I and Se II) against DMBA-induced changes in levels of some [superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) activities and total glutathione (GSH), malonedialdehyde (MDA)] parameters in rat lung and kidney were investigated. As a result, it was found that both Se I and Se II had provided the antioxidant effects against DMBA-induced oxidative stress in rat lung and kidney and lipid peroxidation had also been decreased by these organoselenium compounds. (c) 2007 Elsevier Inc. All rights reserved.
dc.description.sponsorshipTechnological and Scientific Research Council of Turkey TUBITAK [TBAG-2259, 102T185]
dc.description.sponsorshipWe thank to Technological and Scientific Research Council of Turkey TUBITAK TBAG-2259 (102T185) for financial support of this work.
dc.identifier.doi10.1016/j.ecoenv.2007.11.012
dc.identifier.endpage921
dc.identifier.issn0147-6513
dc.identifier.issn1090-2414
dc.identifier.issue3
dc.identifier.pmid18222543
dc.identifier.scopus2-s2.0-59149083390
dc.identifier.scopusqualityQ1
dc.identifier.startpage916
dc.identifier.urihttps://dx.doi.org/10.1016/j.ecoenv.2007.11.012
dc.identifier.urihttps://hdl.handle.net/11480/5079
dc.identifier.volume72
dc.identifier.wosWOS:000263762100036
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor[0-Belirlenecek]
dc.language.isoen
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCE
dc.relation.ispartofECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectDMBA
dc.subjectKidney
dc.subjectLung
dc.subjectOxidative stress
dc.subjectRat
dc.subjectSynthetic organoselenium compounds
dc.titleAntioxidative effects of novel synthetic organoselenium compound in rat lung and kidney
dc.typeArticle

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