The Role of Folic Acid in Rat Embryo Development in a Hypoxic Environment: An Experimental Study

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dc.contributor.authorDagli, Ertugrul
dc.contributor.authorNisari, Mehtap
dc.contributor.authorPatat, Dilara
dc.contributor.authorCayan, Dicle
dc.contributor.authorAtay, Em re
dc.contributor.authorErtekin, Tolga
dc.contributor.authorUcar, Sumeyye
dc.date.accessioned2024-11-07T13:34:56Z
dc.date.available2024-11-07T13:34:56Z
dc.date.issued2024
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractObjective: Folic acid (FA) is a key antioxidant with substantial metabolic roles, and research has demonstrated its effectiveness in reducing congenital anatomical development disorders. This study explores the impact of folic acid on embryo development under hypoxia-induced conditions in embryo cultures. Materials and Methods: Female Wistar albino rats, aged 4-10 months and weighing 150- 250 grams, were utilized for this research. Embryos were extracted from the maternal womb on the 9.5 (th )day of pregnancy. We established six groups, each consisting of 10 embryos: Control (C), Hypoxia (H), 1 mmol FA (1FA), 2 mmol FA (2FA), Hypoxia + 1 mmol FA (H1FA), and Hypoxia + 2 mmol FA (H2FA). Following a 48 -hour culture period, the groups were assessed morphologically. Results: When comparing the morphological parameters of the Control and Hypoxia groups, it was statistically demonstrated that the Control group completed its development, whereas the Hypoxia group exhibited insufficient development (p<0.05). There were statistically significant differences between the Hypoxia group and the Hypoxia + 1 mmol FA and Hypoxia + 2 mmol FA groups (p<0.05). Both the Hypoxia + 1 mmol FA and Hypoxia + 2 mmol FA groups demonstrated better embryonic development compared to the Hypoxia group (p<0.05). Conclusion: The study has established that FA has positive effects on embryos exposed to hypoxic conditions, which result in developmental delays.
dc.description.sponsorshipScientific Research Projects Commission of Erciyes University [TYL-2016-6585]
dc.description.sponsorshipFinancial Disclosure: This study was financially supported by the Scientific Research Projects Commission of Erciyes University (TYL-2016-6585) .
dc.identifier.doi10.14744/cpr.2024.64375
dc.identifier.endpage258
dc.identifier.issn2980-2156
dc.identifier.issue3
dc.identifier.startpage251
dc.identifier.urihttps://doi.org/10.14744/cpr.2024.64375
dc.identifier.urihttps://hdl.handle.net/11480/16248
dc.identifier.volume46
dc.identifier.wosWOS:001244721800005
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherErciyes Univ Sch Medicine
dc.relation.ispartofJournal of Clinical Practice and Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectFolic acid
dc.subjectembryo culture
dc.subjectrat
dc.subjectantioxidant effects
dc.titleThe Role of Folic Acid in Rat Embryo Development in a Hypoxic Environment: An Experimental Study
dc.typeArticle

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