The effect of estradiol on pregnancy rates for luteal phase support in IVF-ICSI-ET agonist cycles

Basit Öğe Kaydı
dc.contributor.authorAkcabay, Cigdem
dc.contributor.authorUrunsak, Ibrahim Ferhat
dc.contributor.authorGulec, Umran Kucukgoz
dc.contributor.authorSucu, Mete
dc.contributor.authorEser, Esra
dc.contributor.authorAtay, Yilmaz
dc.date.accessioned2024-11-07T13:25:26Z
dc.date.available2024-11-07T13:25:26Z
dc.date.issued2021
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractPurpose: The aim of this study was to investigate the effect of transdermal estrogen on pregnancy rates in addition to progesterone for luteal phase support in agonist in-vitro fertilization (IVF) / intracytoplasmic sperm injection (ICSI) / embriyo transfer (ET) cycles. Materials and Methods: This randomized controlled study (RCT) enrolled a total of 142 patients with an indication for IVF/ICSI. We randomized patients prospectively to administer either progesterone (control group n=71) and additionally transdermal estrogen patch (study group n=71) as luteal support after oocyte retrieval. The levels of estrogen was determined on the day of transfer of embryo and 12th day. The main outcome measure was the ongoing pregnancy rate. Both groups were also compared for the induction characteristics, estrogen levels, beta-hCG positivity, and abortion rates. Results: There were no significant differences between the groups according to age, infertility time, and indications. Both groups were similar for induction characteristics and E2 levels. beta-hCG positivity rate was similar and the ongoing pregnancy rate was similar in both groups. Biochemical and clinical abortion rates were also similar in both groups. On the 12th day, estrogen levels increased significantly in those who became pregnant group. Conclusion: Our study showed that adding supplementary estrogen to the progesterone has no positive effect on beta-hCG positivity, ongoing pregnancy, and abortion rates.
dc.identifier.doi10.17826/cumj.735887
dc.identifier.endpage409
dc.identifier.issn2602-3032
dc.identifier.issn2602-3040
dc.identifier.issue2
dc.identifier.startpage403
dc.identifier.urihttps://doi.org/10.17826/cumj.735887
dc.identifier.urihttps://hdl.handle.net/11480/14710
dc.identifier.volume46
dc.identifier.wosWOS:000694865200001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.language.isotr
dc.publisherCukurova Univ, Fac Medicine
dc.relation.ispartofCukurova Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectIVF-ICSI-ET Cycles
dc.subjectGnRH analogues
dc.subjectluteal phase support
dc.subjectprogesterone
dc.subjectestrogen
dc.titleThe effect of estradiol on pregnancy rates for luteal phase support in IVF-ICSI-ET agonist cycles
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu