A Molecular Investigation of Carbapenem Resistant Enterobacteriaceae and blaKPC, blaNDM and blaOXA-48 Genes in Raw Milk

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dc.authoridERTAS ONMAZ, Nurhan/0000-0002-4679-6548
dc.authoridHIZLISOY, Harun/0000-0003-3391-0185
dc.authoridAL, Serhat/0000-0003-2721-9275
dc.contributor.authorAl, Serhat
dc.contributor.authorHizlisoy, Harun
dc.contributor.authorErtas Onmaz, Nurhan
dc.contributor.authorKaradal, Fulden
dc.contributor.authorBarel, Mukaddes
dc.contributor.authorYildirim, Yeliz
dc.contributor.authorGonulalan, Zafer
dc.date.accessioned2024-11-07T13:31:30Z
dc.date.available2024-11-07T13:31:30Z
dc.date.issued2020
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractThe success of antibiotic treatment has been negatively affected due to developing and spreading antimicrobial resistance all over the world. The present study was carried out to reveal the presence of carbapenem resistant Enterobacteriaceae and bla(KPC,) bla(NDM) and bla(OXA-48) genes responsible for carbapenem resistance in raw milk and to contribute to transmission dynamics and molecular epidemiology of carbapenem resistance, as well as the potential public health risks of milk. In Turkey, there is not sufficient data on the presence and the potential risks posed by carbapenem resistance in animal origin foods. A total of different 427 raw milk samples were collected and subjected to phenotypic microbiological analysis and conventional and Sybergreen real-time PCR targeting bla(KPC,) bla(NDM) and bla(OXA-48) genes. In the phenotypic analyses, suspicious isolates were identified by Vitek-2 compact system and antibiotic resistance profiles were revealed. Two Stenotrophomonas maltophilia inherently resistant to carbapenems were detected in raw milk samples. Acquired carbapenem resistance and related genes were not found in any of the milk samples. The present study revealed that milk is not epidemiologically involved in the transmission of carbapenem resistance. In order to prevent the environmental distribution of antibiotic resistant microorganisms, control of antibiotics used in human and veterinary medicine should be maintained.
dc.identifier.doi10.9775/kvfd.2019.23329
dc.identifier.endpage396
dc.identifier.issn1300-6045
dc.identifier.issn1309-2251
dc.identifier.issue3
dc.identifier.scopus2-s2.0-85081273449
dc.identifier.scopusqualityQ3
dc.identifier.startpage391
dc.identifier.urihttps://doi.org/10.9775/kvfd.2019.23329
dc.identifier.urihttps://hdl.handle.net/11480/14872
dc.identifier.volume26
dc.identifier.wosWOS:000519111600012
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherKafkas Univ, Veteriner Fakultesi Dergisi
dc.relation.ispartofKafkas Universitesi Veteriner Fakultesi Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectCarbapenem resistant Enterobacteriaceae
dc.subjectCarbapenemases
dc.subjectRaw milk
dc.titleA Molecular Investigation of Carbapenem Resistant Enterobacteriaceae and blaKPC, blaNDM and blaOXA-48 Genes in Raw Milk
dc.title.alternativeÇiğ sütlerde karbapenem dirençli enterobacteriaceae ve blakpc, blandm ve blaoxa-48 gen varlığının moleküler olarak incelenmesi
dc.typeArticle

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