Bioactivity of etoh and meoh extracts of basidiomycetes mushroom (stereum hirsutum) on atherosclerosis

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dc.contributor.authorSevindik, M.
dc.contributor.authorOzdemir, B.
dc.contributor.authorBal, C.
dc.contributor.authorSelamoglu, Z.
dc.date.accessioned2024-11-07T10:39:39Z
dc.date.available2024-11-07T10:39:39Z
dc.date.issued2021
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractMushrooms are cosmopolitan organisms living on different substrates and have different pharmacological properties, such as antioxidant, antimicrobial, and anti-inflammatory effects thanks to many bioactive compounds. Edible and medicinal higher fungi have been used by humankind for millennia. They are collected and used directly not only for their nutritional values as a main source of food or as a part of a regular diet but also for their medicinal purpose as a source of powerful new bioactive compounds. Antioxidative and anti-inflammatory functions and therefore lipid-lowering effects correlate with antiatherogenic effects. This study determined the total antioxidant capacity (TAS), total oxidant capacity (TOS), oxidative stress index (OSI), 1- diphenyl-2-picrylhydrazyl (DPPH) activity, and antimicrobial activity of ethanolic and methanolic extracts of Stereum hirsutum (Willd.) Pers. Moreover, the effects on atherosclerosis are discussed according to the antioxidant activity of the mushroom. The TAS, TOS, and OSI values of S. hirsutum were determined using Rel Assay kits. According to the results, the TAS, TOS, and OSI values were determined at 5.289±0.113 mmol/L, 20.540±0.416 ?mol/L, and 0.389±0.012. Furthermore, free radical scavenging activity was determined by the DPPH method. The ethanol (EtOH) extracts of S. hirsutum showed higher DPPH activity than methanol extracts. The EtOH extracts at a concentration of 2 mg/mL showed a DPPH inhibition of 45.84±0.81%. Antimicrobial activities were tested on 9 standard bacterial and fungal strains, including Staphylococcus aureus, S. aureus MRSA, Enterococcus faecalis, Escherichia coli, Pseudomonas aeruginosa, Acinetobacter baumannii, Candida albicans, C. krusei, and C. glabrata using a modified agar dilution method. Extracts showed high activity against S. aureus, S. aureus MRSA, and A.baumannii. In conclusion, it was suggested that S. hirsutum can be used as a natural source related to the effects on atherosclerosis due to its antioxidant and antimicrobial activities. © 2021 Razi Vaccine and Serum Research Institute. All rights reserved.
dc.identifier.doi10.22092/ari.2019.126283.1340
dc.identifier.endpage94
dc.identifier.issn0365-3439
dc.identifier.issue1
dc.identifier.pmid33818961
dc.identifier.scopus2-s2.0-85103921046
dc.identifier.scopusqualityQ3
dc.identifier.startpage87
dc.identifier.urihttps://doi.org/10.22092/ari.2019.126283.1340
dc.identifier.urihttps://hdl.handle.net/11480/11109
dc.identifier.volume76
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherRazi Vaccine and Serum Research Institute
dc.relation.ispartofArchives of Razi Institute
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241106
dc.subjectAntimicrobial
dc.subjectAntioxidant
dc.subjectAtherosclerosis
dc.subjectMushroom
dc.subjectStereum hirsutum
dc.titleBioactivity of etoh and meoh extracts of basidiomycetes mushroom (stereum hirsutum) on atherosclerosis
dc.typeArticle

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