Green and Facile Synthesis of Pullulan-Stabilized Silver and Gold Nanoparticles for the Inhibition of Quorum Sensing

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dc.authoridOkan, Meltem/0000-0002-7253-9801
dc.authoridBarsbay, Murat/0000-0003-0788-4446
dc.contributor.authorGhaffarlou, Mohammadreza
dc.contributor.authorIlk, Sedef
dc.contributor.authorHammamchi, Hamideh
dc.contributor.authorKirac, Feyza
dc.contributor.authorOkan, Meltem
dc.contributor.authorGuven, Olgun
dc.contributor.authorBarsbay, Murat
dc.date.accessioned2024-11-07T13:35:16Z
dc.date.available2024-11-07T13:35:16Z
dc.date.issued2022
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractPullulan (Pull) decorated with monodisperse Ag and Au nanoparticles (NPs) was synthesized by a simple and green method. Samples were characterized by FTIR, UV-vis, NMR, XRD, TGA, SEM, XPS, DLS, and TEM. SEM images showed highly oriented microforms reported for the first time for Pull, because of the supramolecular self-assembling behavior of Pull chains. Antimicrobial and quorum sensing (QS) inhibition activities were tested against six pathogen bacteria and reporter and biomonitor strain. Pull decorated with NPs, in particular, Ag-modified ones, outperformed pristine Pull. The cell proliferation was tested with an MTT assay. NPs-decorated Pull was studied for the first time as an inhibitory agent against bacterial signal molecules and found to be a good candidate. The promising performance of AgNPs@Pull compared to the commercial antibiotic gentamicin showed that it has great potential as a therapeutic approach to overcome the bacterial resistance that has developed against conventional antibiotics.
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [217Z069]
dc.description.sponsorshipM.B. acknowledges the financial support of The Scientific and Technological Research Council of Turkey (TUBITAK, 217Z069) for material characterization.
dc.identifier.doi10.1021/acsabm.1c00964
dc.identifier.endpage527
dc.identifier.issn2576-6422
dc.identifier.issue2
dc.identifier.pmid35113519
dc.identifier.scopus2-s2.0-85124652770
dc.identifier.scopusqualityQ1
dc.identifier.startpage517
dc.identifier.urihttps://doi.org/10.1021/acsabm.1c00964
dc.identifier.urihttps://hdl.handle.net/11480/16419
dc.identifier.volume5
dc.identifier.wosWOS:000781540500012
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAmer Chemical Soc
dc.relation.ispartofAcs Applied Bio Materials
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectpullulan
dc.subjectquorum sensing inhibition activity
dc.subjectantimicrobial activity
dc.subjectAg and Au nanoparticles
dc.subjectsupramolecular self-assembly
dc.titleGreen and Facile Synthesis of Pullulan-Stabilized Silver and Gold Nanoparticles for the Inhibition of Quorum Sensing
dc.typeArticle

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