In vitro and in silico approach to determine neuroprotective properties of iridoid glycosides from aerial parts of Scrophularia amplexicaulis by investigating their cholinesterase inhibition and anti-oxidant activities

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dc.authoridSelamoglu, Zeliha/0000-0001-9056-6435
dc.authoridZengin, Gokhan/0000-0001-6548-7823
dc.authoridHamedi, Azadeh/0000-0002-6021-6730
dc.authoridPasdaran, Ardalan/0000-0001-6713-0756
dc.contributor.authorHamedi, Azadeh
dc.contributor.authorZengin, Gokhan
dc.contributor.authorAktumsek, Abdurrahman
dc.contributor.authorSelamoglu, Zeliha
dc.contributor.authorPasdaran, Ardalan
dc.date.accessioned2024-11-07T13:34:16Z
dc.date.available2024-11-07T13:34:16Z
dc.date.issued2020
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractThree iridoid glycosides included 6-O-methyl, 1-glucopyranosyl catalpol (Compound 1), 6-O-a-L (3-O-trans, 4-O-trans cinnamoyl)rhamnopyranosyl catalpol (Compound 2) and scropolioside D (Compound 3) were isolated from aerial parts of S. amplexicaulis using chromatographic methods. The structures were determined by different spectroscopic data. The inhibitory effects (IC50 values) of the compounds on cholinesterase (AChE and BChE) was determined by in-vitro assays. Docking studied were performed to investigate receptor-ligands interactions. The antioxidant capacity was evaluated by 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, 2, 2'azino-bis[3-ethylbenzothiazoline]-6-sulphonic acid (ABTS) radical cation, cupric ion reducing activity (CUPRAC), ferric reducing antioxidant power (FRAP), phosphomolybdenum and metal chelating assays. AChE and BChE were moderately inhibited by all of the investigated iridoid glycosides (compared to galantamine). Compound 2 and compound 3 showed comparable anti-oxidant effects with the Trolox as the control in phosphomolybdenum assay. Also, compound 1, showed acceptable activities in ABTS radical scavenging and Phosphomolybdenum assays compared to the control.
dc.description.sponsorshipShiraz University of Medical Sciences, Shiraz, Iran [98-01-7020391]
dc.description.sponsorshipThis research was supported financially by the Shiraz University of Medical Sciences, Shiraz, Iran (grant number: 98-01-7020391).
dc.identifier.doi10.33263/BRIAC103.429454
dc.identifier.endpage5454
dc.identifier.issn2069-5837
dc.identifier.issue3
dc.identifier.scopus2-s2.0-85085574569
dc.identifier.scopusqualityQ3
dc.identifier.startpage5429
dc.identifier.urihttps://doi.org/10.33263/BRIAC103.429454
dc.identifier.urihttps://hdl.handle.net/11480/15883
dc.identifier.volume10
dc.identifier.wosWOS:000522548200015
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherAmg Transcend Assoc
dc.relation.ispartofBiointerface Research in Applied Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectAnti-oxidant
dc.subjectAcetylcholinesterase
dc.subjectButyrylcholinesterase
dc.subjectIridoid glycosides
dc.subjectAlzheimer's disease
dc.subjectneuroprotective
dc.titleIn vitro and in silico approach to determine neuroprotective properties of iridoid glycosides from aerial parts of Scrophularia amplexicaulis by investigating their cholinesterase inhibition and anti-oxidant activities
dc.typeArticle

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