Dietary rumen-protected L-arginine or N-carbamylglutamate enhances placental amino acid transport and suppresses angiogenesis and steroid anabolism in underfed pregnant ewes

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dc.authoridElsabagh, Mabrouk/0000-0002-0596-6547
dc.authoridZhang, Hao/0000-0002-5046-9785
dc.contributor.authorZhang, Hao
dc.contributor.authorZha, Xia
dc.contributor.authorZhang, Bei
dc.contributor.authorZheng, Yi
dc.contributor.authorLiu, Xiaoyun
dc.contributor.authorElsabagh, Mabrouk
dc.contributor.authorMa, Yi
dc.date.accessioned2024-11-07T13:34:49Z
dc.date.available2024-11-07T13:34:49Z
dc.date.issued2023
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractThis study aimed to investigate the effects of dietary supplementation of underfed Hu ewes from d 35 to 110 of gestation with either rumen-protected L-arginine (RP-Arg) or N-carbamylglutamate (NCG) on placental amino acid (AA) transport, angiogenic gene expression, and steroid anabolism. On d 35 of gestation, 32 Hu ewes carrying twin fetuses were randomly divided into four treatment groups, each consisting of eight ewes, and were fed the following diets: A diet providing 100% of NRC's nutrient requirements for pregnant ewes (CON); A diet providing 50% of NRC's nutrient requirements for pregnant ewes (RES); RES diet plus 5 g/d NCG (RES + NCG); or RES diet plus 20 g/d RP-Arg (RES + ARG). On the d 110 of pregnancy, blood samples were taken from the mother, and samples were collected from type A cotyledons (COT; the fetal portions of the placenta). The levels of 17 beta-estradiol and progesterone in the maternal serum and both the capillary area density (CAD) and capillary surface density (CSD) in type A COT were decreased in response to Arg or NCG supplementation when compared to the RES group. The concentrations of arginine, leucine, putrescine and spermidine in type A COT were higher (P < 0.05) in the RES + ARG or RES + NCG group than in the RES group. The mRNA expression levels of inducible nitric oxide synthase (iNOS) and solute carrier family 15, member 1 (SLC15A1) were increased (P < 0.05) while those of progesterone receptor (PGR) and fibroblast growth factor 2 (FGF2) were decreased in type A COT by supplementation with either NCG or RP-Arg compared to the RES group. The results suggest that providing underfed pregnant ewes from d 35 to 110 of gestation with a diet supplemented with NCG or RP-Arg improves placental AA transport, and reduces the expression of angiogenic growth factor genes and steroid anabolism, leading to better fetal development.(c) 2023 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
dc.description.sponsorshipFund for the Top Talents Award Plan of Yangzhou University; Cyanine Project of Yangzhou University
dc.description.sponsorshipThe research was supported by the fund for the Top Talents Award Plan of Yangzhou University (2020) and the Cyanine Project of Yangzhou University (2020) .
dc.identifier.doi10.1016/j.aninu.2023.08.005
dc.identifier.endpage158
dc.identifier.issn2405-6383
dc.identifier.issn2405-6545
dc.identifier.pmid38023379
dc.identifier.scopus2-s2.0-85176380746
dc.identifier.scopusqualityQ1
dc.identifier.startpage149
dc.identifier.urihttps://doi.org/10.1016/j.aninu.2023.08.005
dc.identifier.urihttps://hdl.handle.net/11480/16162
dc.identifier.volume15
dc.identifier.wosWOS:001108384500001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherKeai Publishing Ltd
dc.relation.ispartofAnimal Nutrition
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectAngiogenesis factor
dc.subjectL-arginine
dc.subjectN-carbamylglutamate
dc.subjectPlacental amino acid transport
dc.subjectPregnant ewes
dc.subjectSteroid anabolism
dc.titleDietary rumen-protected L-arginine or N-carbamylglutamate enhances placental amino acid transport and suppresses angiogenesis and steroid anabolism in underfed pregnant ewes
dc.typeArticle

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