Royal jelly protection on flunixin meglumine-induced spermiotoxicity and testicular degeneration in mice

Basit Öğe Kaydı
dc.contributor.authorTemamogullari, F.
dc.contributor.authorAral, F.
dc.contributor.authorYilmaz, R.
dc.date.accessioned2019-08-01T13:38:39Z
dc.date.available2019-08-01T13:38:39Z
dc.date.issued2018
dc.departmentNiğde ÖHÜ
dc.description.abstractCurrent study was designed to investigate the protective effects of royal jelly on Flunixin meglumine (FM)-induced spermiotoxicity related to sperm concentration, abnormal spermatozoa count and histopathological changes in mice testis. The subjects were divided into five groups according to FM and/or royal jelly intake: Control group; group 1, FM alone (25 mg/kg, im); group 2, combination of FM (25 mg/kg, im) and royal jelly (200 mg/kg, oral); group 3, FM alone (50 mg/kg, iin); and group 4, combination of FM (50 mg/kg, im) and royal jelly (200 mg/kg, oral). The animals were fed once daily for 15 days and they were sacrificed last day. Epididymal sperm concentration and abnormal spermatozoa count were noted. Testicular histological findings were evaluated. On purpose, organization of each animal was graded according to Johnsen's scoring to assess the spermatogenesis relying on seminiferous tubule cross-section scores. Comparing to controls, FM administration caused a decrease in sperm concentration (p<0.05), an increase in total abnormal spermatozoa rates (p< 0.05) and more degenerative changes in testes in mice. Royal jelly supplementation ameliorated both sperm concentration and abnormal spermatozoa (p<0.05) comparing to the control group. In conclusion, we suggested that royal jelly might have protective effects in the FM-induced reductions in epididymal sperm concentration and increase in abnormal spermatozoa rate.
dc.identifier.doi10.24425/122624
dc.identifier.endpage506
dc.identifier.issn1505-1773
dc.identifier.issn2300-2557
dc.identifier.issue3
dc.identifier.pmid30468347
dc.identifier.scopus2-s2.0-85057101640
dc.identifier.scopusqualityQ3
dc.identifier.startpage497
dc.identifier.urihttps://dx.doi.org/10.24425/122624
dc.identifier.urihttps://hdl.handle.net/11480/3483
dc.identifier.volume21
dc.identifier.wosWOS:000450720700011
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor[0-Belirlenecek]
dc.language.isoen
dc.publisherPOLSKA AKAD NAUK, POLISH ACAD SCIENCES, UNIV WARMIA & MAZURY OLSZTYN
dc.relation.ispartofPOLISH JOURNAL OF VETERINARY SCIENCES
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectflunixin meglumine
dc.subjectroyal jelly
dc.subjectmale mice
dc.subjectsperm
dc.subjecttestes toxicity
dc.titleRoyal jelly protection on flunixin meglumine-induced spermiotoxicity and testicular degeneration in mice
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu