Investigation of the protective effects of crocin on acrylamide induced small and large intestine damage in rats

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dc.contributor.authorGedik S.
dc.contributor.authorErdemli M.E.
dc.contributor.authorGul M.
dc.contributor.authorYigitcan B.
dc.contributor.authorGozukara Bag H.
dc.contributor.authorAksungur Z.
dc.contributor.authorAltinoz E.
dc.date.accessioned2019-08-01T13:38:39Z
dc.date.available2019-08-01T13:38:39Z
dc.date.issued2018
dc.departmentNiğde ÖHÜ
dc.description.abstractWe investigated repair of acrylamide (AA) induced damage in intestines by administration of crocin. We used 40 male Wistar rats in four groups of 10 animals: control, AA, crocin, and AA + crocin groups. We investigated biochemical and histological changes to small and large intestine. AA ingestion decreased glutathione (GSH) levels and total antioxidant status (TAS) in the intestine compared to the control group, while superoxide dismutase (SOD) and catalase (CAT) activities, and total oxidant status (TOS) and malondialdehyde (MDA) levels were increased. Villi were shortened and villus degeneration was observed in ileum of the AA group. Degeneration of surface epithelium and Liberkühn crypts were observed in colon sections. GSH and TAS levels increased after administration of AA together with crocin, while SOD and CAT levels and TOS and MDA levels decreased; significant recovery of histological damage also was observed. We found that crocin exhibits protective effects on AA induced small and large intestine damage by inhibiting oxidative stress. © 2018, © 2018 The Biological Stain Commission.
dc.description.sponsorshipKarabük Üniversitesi
dc.description.sponsorshipThis work was supported by Research Fund of the Karabuk University [KBU-BAP-15/2-YL-010]; Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this paper.
dc.identifier.doi10.1080/10520295.2018.1432888
dc.identifier.endpage276
dc.identifier.issn1052-0295
dc.identifier.issue4
dc.identifier.pmid29644878
dc.identifier.scopus2-s2.0-85045270681
dc.identifier.scopusqualityQ2
dc.identifier.startpage267
dc.identifier.urihttps://dx.doi.org/10.1080/10520295.2018.1432888
dc.identifier.urihttps://hdl.handle.net/11480/1653
dc.identifier.volume93
dc.identifier.wosWOS:000440041100005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor[0-Belirlenecek]
dc.language.isoen
dc.publisherTaylor and Francis Ltd
dc.relation.ispartofBiotechnic and Histochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectacrylamide
dc.subjectcrocin
dc.subjectlarge intestine
dc.subjectoxidative stress
dc.subjectrats
dc.subjectsmall intestine
dc.titleInvestigation of the protective effects of crocin on acrylamide induced small and large intestine damage in rats
dc.typeArticle

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