The relationship between neutrophil/lymphocyte ratio and uric acid levels in multiple sclerosis patients

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dc.contributor.authorBolayir, A.
dc.contributor.authorCigdem, B.
dc.contributor.authorGokce, S. F.
dc.contributor.authorYilmaz, D.
dc.date.accessioned2024-11-07T13:31:44Z
dc.date.available2024-11-07T13:31:44Z
dc.date.issued2021
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractBACKGROUND: In this study, we aimed to determine whether neutrophil / lymphocyte ratio (NLR), obtained by dividing the number of neutrophils by the number of lymphocytes, and uric acid (UA) levels in multiple sclerosis (MS) patients vary compared with healthy controls and to establish correlations among these changes themselves as well as between such changes and MS subtypes, immunomodulatory drug use, the duration of the disease and prognosis. METHODS: 150 patients who presented to our hospital and were diagnosed with MS and 150 healthy volunteers were retrospectively included in our study. EDSS score (Expanded Disability Status Scale) was used to assess the disability of the patients. RESULTS: Compared to healthy volunteers, MS patients had lower UA levels (p < 0.001) and higher NLR values (p = 0.02). In addition, UA levels were higher in patients with a low EDSS score or those on immunomodulating drugs (p < 0.001, p = 0.04, respectively). NLR value was lower in patients with a low EDSS score (p < 0.001). There was a negative correlation between NLR value and UA (r = -0.23, p = 0.003). Similarly, UA level decreased with increasing EDSS score and duration of disease (r = -0.38, p < 0.001; r = -0.17, p = 0.02, respectively). CONCLUSION: Evaluating the NLR value, recognized as a new marker for inflammation in MS, together with the UA value, thought to be protective in MS, might be more effective than evaluating these parameters alone in demonstrating disability in patients (Tab. 4, Ref. 28).
dc.identifier.doi10.4149/BLL_2021_060
dc.identifier.endpage361
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.issue5
dc.identifier.pmid33848187
dc.identifier.scopus2-s2.0-85104367132
dc.identifier.scopusqualityQ3
dc.identifier.startpage357
dc.identifier.urihttps://doi.org/10.4149/BLL_2021_060
dc.identifier.urihttps://hdl.handle.net/11480/15020
dc.identifier.volume122
dc.identifier.wosWOS:000647174500011
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAepress Sro
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectneutrophil/lymphocyte ratio
dc.subjecturic acid
dc.subjectmultiple sclerosis
dc.subjectinflammation
dc.subjectExpanded Disability Status Scale
dc.titleThe relationship between neutrophil/lymphocyte ratio and uric acid levels in multiple sclerosis patients
dc.typeArticle

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