The effect of ionizing radiation on the fetal bone development in pregnant rats: Role of melatonin

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dc.authoridTokpinar, Adem/0000-0001-7661-9588
dc.contributor.authorTokpinar, Adem
dc.contributor.authorNisari, Mehtap
dc.contributor.authorYilmaz, Seher
dc.contributor.authorYay, Arzu
dc.contributor.authorYildiz, Oguz Galip
dc.contributor.authorBalcioglu, Esra
dc.contributor.authorAlisan, Pinar
dc.date.accessioned2024-11-07T13:35:12Z
dc.date.available2024-11-07T13:35:12Z
dc.date.issued2024
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractRadiation has been widely used in many business sectors over the last century. Our study investigated the possible teratogenic effects of radiation on the bones of rat fetuses and the protective effect of melatonin against these effects. In this study, 15 pregnant female Wistar albino rats were used. These rats were divided into four groups: the control group, melatonin group (10 mg/kg/day), radiation group (0.5 gray), radiation (0.5 gray) + melatonin group (10 mg/kg/day), and sham group (1 mm hanks/day). The skeletal system development of fetuses was examined with double skeletal and scanning electron microscope (SEM), histopathological methods. In our study, fetal weight, placental weight, and fetal morphometric values were found to be statistically significantly decreased in the radiation group compared to the control group (p < .05). In immunohistochemistry (IHC) analysis, alkaline phosphatase, and tartrate-resistant acid phosphatase) concentrations were found to be significantly lower in the radiation group compared to the other groups. In the SEM analysis, it was observed that the amount of calcium and sodium decreased when the radiation group was compared with the other groups. As a result, when exposed to ionizing radiation during pregnancy, melatonin has a protective feature against the negative effects of radiation on the bone development of fetuses.
dc.description.sponsorshipThis research was the basis of Adem Tokpinaramp;apos;s PhD thesis. This study was approved by Erciyes University Animal Experiments Ethic Committee. The authors are grateful to the Erciyes University Clinical Research Center for their support.
dc.description.sponsorshipThis research was the basis of Adem Tokpinar & apos;s PhD thesis. This study was approved by Erciyes University Animal Experiments Ethic Committee. The authors are grateful to the Erciyes University Clinical Research Center for their support.
dc.identifier.doi10.1002/jemt.24414
dc.identifier.endpage104
dc.identifier.issn1059-910X
dc.identifier.issn1097-0029
dc.identifier.issue1
dc.identifier.pmid37705325
dc.identifier.scopus2-s2.0-85170695571
dc.identifier.scopusqualityQ1
dc.identifier.startpage95
dc.identifier.urihttps://doi.org/10.1002/jemt.24414
dc.identifier.urihttps://hdl.handle.net/11480/16374
dc.identifier.volume87
dc.identifier.wosWOS:001066479800001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofMicroscopy Research and Technique
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241106
dc.subjectdouble skeletal staining
dc.subjectradiation
dc.subjectrat
dc.titleThe effect of ionizing radiation on the fetal bone development in pregnant rats: Role of melatonin
dc.typeArticle

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