Polyphenols: Well Beyond The Antioxidant Capacity: Gallic Acid and Related Compounds as Neuroprotective Agents: You are What You Eat!

Basit Öğe Kaydı
dc.contributor.authorDaglia, Maria
dc.contributor.authorDi Lorenzo, Arianna
dc.contributor.authorNabavi, Seyed F.
dc.contributor.authorTalas, Zeliha S.
dc.contributor.authorNabavi, Seyed M.
dc.date.accessioned2019-08-01T13:38:39Z
dc.date.available2019-08-01T13:38:39Z
dc.date.issued2014
dc.departmentNiğde ÖHÜ
dc.description.abstractGallic acid (3,4,5-trihydroxybenzoic acid) is a phenolic acid widely distributed in many different families of higher plants, both in free state, and as a part of more complex molecules, such as ester derivatives or polymers. In nature, gallic acid and its derivatives are present in nearly every part of the plant, such as bark, wood, leaf, fruit, root and seed. They are present in different concentrations in common foodstuffs such as blueberry, blackberry, strawberry, plums, grapes, mango, cashew nut, hazelnut, walnut, tea, wine and so on. After consumption, about 70% of gallic acid is adsorbed and then excreted in the urine as 4-O-methylgallic acid. Differently, the ester derivatives of gallic acid, such as catechin gallate ester or gallotannins, are hydrolyzed to gallic acid before being metabolized to methylated derivatives. Gallic acid is a well known antioxidant compounds which has neuroprotective actions in different models of neurodegeneration, neurotoxicity and oxidative stress. In this review, we discuss about the neuroprotective actions of gallic acid and derivatives and their potential mechanisms of action.
dc.identifier.doi10.2174/138920101504140825120737
dc.identifier.endpage372
dc.identifier.issn1389-2010
dc.identifier.issn1873-4316
dc.identifier.issue4
dc.identifier.pmid24938889
dc.identifier.scopus2-s2.0-84907307862
dc.identifier.scopusqualityQ2
dc.identifier.startpage362
dc.identifier.urihttps://dx.doi.org/10.2174/138920101504140825120737
dc.identifier.urihttps://hdl.handle.net/11480/4241
dc.identifier.volume15
dc.identifier.wosWOS:000340715400008
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor[0-Belirlenecek]
dc.language.isoen
dc.publisherBENTHAM SCIENCE PUBL LTD
dc.relation.ispartofCURRENT PHARMACEUTICAL BIOTECHNOLOGY
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectGallic acid
dc.subjectneuroprotective activity
dc.subjectpolyphenos
dc.subjectprotective activity
dc.titlePolyphenols: Well Beyond The Antioxidant Capacity: Gallic Acid and Related Compounds as Neuroprotective Agents: You are What You Eat!
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu