Investigation of the effect of Myricetin on Cisplatin-induced liver hepatotoxicity

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dc.contributor.authorAksoy, Suemeyye
dc.contributor.authorKuloglu, Nurhan
dc.contributor.authorKarabulut, Derya
dc.contributor.authorYakan, Birkan
dc.date.accessioned2024-11-07T13:32:02Z
dc.date.available2024-11-07T13:32:02Z
dc.date.issued2024
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractOBJECTIVE: Cisplatin, a widely used anticancer agent, induces hepatotoxicity alongside organ damage. Understanding Cisplatin's toxicity mechanism and developing preventive measures are crucial. Our study explores Myricetin, a flavonoid, for its protective effects against Cisplatin-induced hepatotoxicity. METHODS: In our study, a total of 32 Wistar albino male rats were utilized, which were categorized into four distinct groups: Control, Myricetin, Cisplatin, and Myricetin+Cisplatin. For the histological assessment of hepatic tissues, hematoxylin-eosin and periodic acid Schiff staining were employed, alongside immunohistochemical measurements of TNF-alpha, alpha, interleukin-17, and interleukin-6 immunoreactivity. Additionally, aspartate transaminase and alanine transaminase values were examined by biochemical analysis. RESULTS: In the histological evaluation of the tissues, a normal healthy cell structure and a strong periodic acid Schiff (+) reaction were observed in the hepatocyte cells in the tissues of the Control and Myricetin groups, while intense eosinophilia, minimal vacuolization, congestion, and sinusoidal expansions were observed in the hematoxylin-eosin stainings, and a decrease in the positive reaction in the periodic acid Schiff staining was observed in the Cisplatin group. Consistent with these histological findings, an increase in TNF-alpha, alpha, interleukin-17, and interleukin-6 expressions (p<0.0001) and a concomitant increase in aspartate transaminase and alanine transaminase values were observed in the Cisplatin group. In the group protected by Myricetin, a significant improvement was observed in all these histological and biochemical values. CONCLUSION: Cisplatin induces notable histopathological alterations in the liver. In this context, Myricetin exhibits the potential to alleviate Cisplatininduced damage by modulating histological parameters and biochemical processes.
dc.description.sponsorshipErciyes University's Scientific Research Projects Unit [TYL-2021-11547]
dc.description.sponsorshipOur study was financially supported by Erciyes University's Scientific Research Projects Unit, TYL-2021-11547 project code.
dc.identifier.doi10.1590/1806-9282.20240136
dc.identifier.issn0104-4230
dc.identifier.issn1806-9282
dc.identifier.issue7
dc.identifier.pmid39045937
dc.identifier.scopus2-s2.0-85199394109
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1590/1806-9282.20240136
dc.identifier.urihttps://hdl.handle.net/11480/15179
dc.identifier.volume70
dc.identifier.wosWOS:001276117100001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAssoc Medica Brasileira
dc.relation.ispartofRevista Da Associacao Medica Brasileira
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectAntioxidant
dc.subjectCisplatin
dc.subjectMyricetin
dc.subjectHepatotoxicity
dc.subjectRat
dc.titleInvestigation of the effect of Myricetin on Cisplatin-induced liver hepatotoxicity
dc.typeArticle

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