Dietary Supplementation of L-Arginine and N-Carbamylglutamate Attenuated the Hepatic Inflammatory Response and Apoptosis in Suckling Lambs with Intrauterine Growth Retardation

Basit Öğe Kaydı
dc.authoridJiang, Honghua/0000-0003-3728-3932
dc.authoridElsabagh, Mabrouk/0000-0002-0596-6547
dc.contributor.authorZhang, Hao
dc.contributor.authorFan, Yaotian
dc.contributor.authorElsabagh, Mabrouk
dc.contributor.authorGuo, Shuang
dc.contributor.authorWang, Mengzhi
dc.contributor.authorJiang, Honghua
dc.date.accessioned2024-11-07T13:34:43Z
dc.date.available2024-11-07T13:34:43Z
dc.date.issued2020
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractL-arginine (Arg) is a semiessential amino acid with several physiological functions. N-Carbamylglutamate (NCG) can promote the synthesis of endogenous Arg in mammals. However, the roles of Arg or NCG on hepatic inflammation and apoptosis in suckling lambs suffering from intrauterine growth restriction (IUGR) are still unclear. The current work is aimed at examining the effects of dietary Arg and NCG on inflammatory and hepatocyte apoptosis in IUGR suckling lambs. On day 7 after birth, 48 newborn Hu lambs were selected from a cohort of 432 twin lambs. Normal-birthweight and IUGR Hu lambs were allocated randomly (n=12/group) to control (CON), IUGR, IUGR+1% Arg, or IUGR+0.1% NCG groups. Lambs were fed for 21 days from 7 to 28 days old. Compared with CON lambs, relative protein 53 (P53), apoptosis antigen 1 (Fas), Bcl-2-associated X protein (Bax), caspase-3, cytochrome C, tumor necrosis factor alpha (TNF-alpha), nuclear factor kappa-B (NF-kappa B) p65, and NF-kappa B pp65 protein levels were higher (P<0.05) in liver from IUGR lambs, whereas those in liver from IUGR lambs under Arg or NCG treatment were lower than those in IUGR lambs. These findings indicated that supplementing Arg or NCG reduced the contents of proinflammatory cytokines at the same time when the apoptosis-related pathway was being suppressed, thus suppressing the IUGR-induced apoptosis of hepatic cells.
dc.description.sponsorshipNational Natural Science Foundation of China [31902180]; Research Project of the Natural Science Foundation of Jiangsu Province [BK20170488]; China Postdoctoral Science Foundation [2017M610358]; Su Bei Special Science and Technology Foundation [SZ-HA 2017008]; Yangzhou University Science and Technology Innovation Foundation [2017 CXJ 081]
dc.description.sponsorshipThe research was supported by funding from the National Natural Science Foundation of China (grant number 31902180), the Research Project of the Natural Science Foundation of Jiangsu Province (BK20170488), the China Postdoctoral Science Foundation (2017M610358), the Su Bei Special Science and Technology Foundation (SZ-HA 2017008), and the Yangzhou University Science and Technology Innovation Foundation (2017 CXJ 081).
dc.identifier.doi10.1155/2020/2453537
dc.identifier.issn0962-9351
dc.identifier.issn1466-1861
dc.identifier.pmid32322162
dc.identifier.scopus2-s2.0-85083741451
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1155/2020/2453537
dc.identifier.urihttps://hdl.handle.net/11480/16141
dc.identifier.volume2020
dc.identifier.wosWOS:000526765300002
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherHindawi Ltd
dc.relation.ispartofMediators of Inflammation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectRumen-Protected Arginine
dc.subjectFetal-Growth
dc.subjectMessenger-Rna
dc.subjectRestriction
dc.subjectExpression
dc.subjectCaspases
dc.subjectNutrition
dc.subjectLiver
dc.subjectConsequences
dc.subjectMorphology
dc.titleDietary Supplementation of L-Arginine and N-Carbamylglutamate Attenuated the Hepatic Inflammatory Response and Apoptosis in Suckling Lambs with Intrauterine Growth Retardation
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu