Effects of 2-Aminoethyl Diphenylborinate, a Modulator of Transient Receptor Potential and Orai Channels in Subarachnoid Hemorrhage: An Experimental Study

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dc.contributor.authorBoyacı M.G.
dc.contributor.authorRakip U.
dc.contributor.authorAslan A.
dc.contributor.authorKoca H.B.
dc.contributor.authorAslan E.
dc.contributor.authorKorkmaz S.
dc.contributor.authorYıldızhan S.
dc.date.accessioned2019-08-01T13:38:39Z
dc.date.available2019-08-01T13:38:39Z
dc.date.issued2019
dc.departmentNiğde ÖHÜ
dc.description.abstractBackground: Cerebral vasospasm remains a serious problem affecting morbidity and mortality in patients with subarachnoid hemorrhage (SAH) during neurosurgery. We aimed to demonstrate the role of the transient receptor potential channel and other channels for Ca2+ in the etiology of cerebral vasospasm using 2-aminoethyl diphenylborinate (2-APB) and the effective dose range of an unstudied pharmacological agent, which can limit vasospasm. Methods: We performed an experimental study using 32 Sprague-Dawley rats divided into 4 groups: sham group (n = 8), SAH group (n = 8), 2-APB group (SAH rats intraperitoneally administered with 0.5 mg/kg 2-APB; n = 8), and 2-APB-2 group (SAH rats intraperitoneally administered with 2 mg/kg 2-APB; n = 8). The rats were sacrificed after 24 hours, and superoxide dismutase, glutathione peroxidase, malondialdehyde, tumor necrosis factor-?, and interleukin-1ß in the brain tissue and serum were measured. The histopathological investigation of brain tissue included measurement of the luminal diameter and wall thickness of the basilar artery (BA), and apoptotic cells in the hippocampus were counted after caspase staining. Results: Autologous arterial blood injection into the cisterna magna caused vasospasm in rats. 2-APB treatment increased the BA wall thickness and reduced the BA lumen diameter, inducing significant vascular changes. 2-APB also alleviated cell apoptosis at 24 hours after SAH. Conclusion: In experimental SAH in rats, 2-APB treatment increased the BA wall thickness and reduced the BA lumen diameter, inducing significant vascular changes. 2-APB also alleviated cell apoptosis at 24 hours after SAH. © 2019 Elsevier Inc.
dc.identifier.doi10.1016/j.wneu.2019.03.129
dc.identifier.endpagee388
dc.identifier.issn1878-8750
dc.identifier.pmid30905651
dc.identifier.scopus2-s2.0-85064519050
dc.identifier.scopusqualityQ2
dc.identifier.startpagee376
dc.identifier.urihttps://dx.doi.org/10.1016/j.wneu.2019.03.129
dc.identifier.urihttps://hdl.handle.net/11480/1464
dc.identifier.volume127
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor[0-Belirlenecek]
dc.language.isoen
dc.publisherElsevier Inc.
dc.relation.ispartofWorld Neurosurgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subject2-Aminoethyl diphenylborate
dc.subjectCa2+ channels
dc.subjectCerebral vasospasm
dc.subjectOrai channels
dc.subjectSubarachnoid hemorrhage
dc.subjectTRP channels
dc.titleEffects of 2-Aminoethyl Diphenylborinate, a Modulator of Transient Receptor Potential and Orai Channels in Subarachnoid Hemorrhage: An Experimental Study
dc.typeArticle

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