Impact of Bisphenol A exposure on maternal gut microbial homeostasis, placental function, and fetal development during pregnancy

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dc.contributor.authorZha, Xia
dc.contributor.authorElsabagh, Mabrouk
dc.contributor.authorZheng, Yi
dc.contributor.authorZhang, Bei
dc.contributor.authorWang, Hongrong
dc.contributor.authorBai, Yila
dc.contributor.authorZhao, Jingwen
dc.date.accessioned2024-11-07T13:35:13Z
dc.date.available2024-11-07T13:35:13Z
dc.date.issued2024
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractPregnancy is extremely vulnerable to external environmental influences. Bisphenol A, an endocrine-disrupting chemical, poses a significant environmental hazard to individuals of all ages and stages, particularly during pregnancy. The placenta is a temporary organ facilitating the connection between the mother and fetus. While it can detoxify certain exogenous substances, it is also vulnerable to the impacts of endocrine disruptors. Likewise, the intestinal flora is highly sensitive to exogenous stresses and environmental pollutants. The regulation of gut microbiota plays a crucial role in ensuring the health of both the mother and the fetus. The gut-placental axis connects the gut, gut microbes, placenta, and fetus. Exploring possible effects on placental function and fetal development involves analyzing changes in gut microbiota composition. Given that bisphenol A may cross the intestine and affect intestinal function, gut microorganisms, and their metabolites, as well as its potential impact on the placenta, resulting in impaired placental function and fetal development, this study aims to establish a link between bisphenol A exposure, intestinal microorganisms, placental function, and fetal development. This paper seeks to analyze the effects of maternal exposure to bisphenol A during pregnancy on the balance of the maternal gut microbiota, placental function, and fetal development, considering the key role of the gut-placental axis. Additionally, this paper proposes potential directions for future research emphasizing the importance of mitigating the adverse outcomes of bisphenol A exposure during pregnancy in both human and animal studies.
dc.description.sponsorshipFund for the Project of the National Key Research and Development Program of China [2023YFD1301705]; Yangzhou University
dc.description.sponsorshipThe research was supported by the fund for the Project of the National Key Research and Development Program of China (2023YFD1301705), the Top Talents Award Plan of Yangzhou University (2020), and the Cyanine Project of Yangzhou University (2020) .
dc.identifier.doi10.1016/j.reprotox.2024.108677
dc.identifier.issn0890-6238
dc.identifier.issn1873-1708
dc.identifier.pmid39067774
dc.identifier.scopus2-s2.0-85199701893
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.reprotox.2024.108677
dc.identifier.urihttps://hdl.handle.net/11480/16381
dc.identifier.volume129
dc.identifier.wosWOS:001284349400001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofReproductive Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241106
dc.subjectGut microbiota
dc.subjectBisphenol A
dc.subjectPregnancy
dc.subjectPlacenta
dc.subjectFetal development
dc.subjectGut-placental axis
dc.titleImpact of Bisphenol A exposure on maternal gut microbial homeostasis, placental function, and fetal development during pregnancy
dc.typeReview Article

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