The investigation of antioxidant and anti-inflammatory potentials of apitherapeutic agents on heart tissues in nitric oxide synthase inhibited rats via N?-nitro-L-arginine methyl ester

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dc.contributor.authorOzdemir, Betul
dc.contributor.authorGulhan, Mehmet Fuat
dc.contributor.authorSahna, Engin
dc.contributor.authorSelamoglu, Zeliha
dc.date.accessioned2024-11-07T13:34:30Z
dc.date.available2024-11-07T13:34:30Z
dc.date.issued2021
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractBackground High blood pressure effects heart and vessels. Development of pathogenesis is the result of oxidative stress. We aimed to investigate the antioxidant effects of propolis, caffeic acid phenethyl ester (CAPE), and pollen on the hearts of rats which chronic nitric oxide synthase (NOS) inhibited through N omega-nitro-L-arginine methyl ester (L-NAME). Paraoxonase 1 (PON1), total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), asymmetric dimethylarginine (ADMA), and nuclear factor-kappa B (NF-kappa B) were analyzed on the heart. Material and Methods Sprague-Dawley rats were divided five groups of seven rats in every group; Group I: Control, Group II: L-NAME, Group III: L-NAME+propolis, Group IV: L-NAME+CAPE and Group V: L-NAME+pollen. L-NAME become dissolved in regular saline (0.9% NaCl w/v). The ethanolic extract of propolis (200 mg/kg/days, gavage), pollen (100 mg/kg/days, by gavage), CAPE (50 mu M/kg/days, intraperitoneally), and the NOS inhibitor L-NAME (40 mg/kg, intraperitoneally) had been administered. Results Blood pressure (BP) of rats treated with propolis, CAP,E and pollen statistically significant decreased. Decreasing in BP of the rats of pollen group was more than CAPE and propolis groups (P< .05). PON1 and TAS levels decreased in L-NAME-treated groups (P< .05), but ranges have been better in propolis, CAPE and pollen groups. TOS, ADMA and NF-kappa B levels increased (P< .05) in L-NAME group; however, these parameters were lower (P< .05) in propolis and CAPE groups (P< .05). Conclusions Vasorelaxant properties and free radical scavenging actions of propolis, CAPE, and pollen may reduce the oxidative stress and blood pressure in the rats chronic NOS inhibited through L-NAME.
dc.description.sponsorshipNigde Omer Halisdemir University (Turkey) Research Fund [BAP 2012/38]
dc.description.sponsorshipThis work was supported by the Nigde Omer Halisdemir University (Turkey) Research Fund [Project number: BAP 2012/38].
dc.identifier.doi10.1080/10641963.2020.1806294
dc.identifier.endpage76
dc.identifier.issn1064-1963
dc.identifier.issn1525-6006
dc.identifier.issue1
dc.identifier.pmid32799699
dc.identifier.scopus2-s2.0-85089514056
dc.identifier.scopusqualityQ3
dc.identifier.startpage69
dc.identifier.urihttps://doi.org/10.1080/10641963.2020.1806294
dc.identifier.urihttps://hdl.handle.net/11480/16023
dc.identifier.volume43
dc.identifier.wosWOS:000560550100001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Inc
dc.relation.ispartofClinical and Experimental Hypertension
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241106
dc.subjectAnti-inflammatory effect
dc.subjectantioxidant
dc.subjectapitheraphy
dc.subjectheart
dc.subjecthypertension
dc.subjectoxidative stress
dc.subjectrat
dc.titleThe investigation of antioxidant and anti-inflammatory potentials of apitherapeutic agents on heart tissues in nitric oxide synthase inhibited rats via N?-nitro-L-arginine methyl ester
dc.typeArticle

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