Genetic Variations in Nrf2-Keap1 Complex: A Step towards Understanding Cancer Resistance in Blind Mole Rats Cytotypes

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dc.contributor.authorAkin-Bali, Dilara Fatma
dc.contributor.authorKankilic, Teoman
dc.date.accessioned2024-11-07T13:25:04Z
dc.date.available2024-11-07T13:25:04Z
dc.date.issued2019
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractThe Nrf2-Keap1 regulation system plays a crucial role in cytoprotection against electrophilic/oxidative stress. Previous studies have identified missense mutations in Nrf2/Keap1 complex which abolish its activity. The amino acid corresponding to codon 212 in Keapl's IVR domain is conserved as tyrosine (Y) among different mammalian species whereas only Nannospalax and two other species carry a cysteine (C) residue at this position. These species include Sperm whale and European hedgehog that live in hypoxic environment. In this study, we examined genetic variations in Nrf2-Keap1 complex, which was reported to be important in cancer pathogenesis in previous studies, in cancer resistant blind mole rat species with varying chromosome numbers (2n: 46-60) that we collected from different regions in Turkey. This study was the first to provide information on genetic variants in Nrf2/Keap1 complex of blind mole rats living in Turkey.
dc.identifier.doi10.1134/S1062359019060050
dc.identifier.endpage554
dc.identifier.issn1062-3590
dc.identifier.issn1608-3059
dc.identifier.issue6
dc.identifier.scopus2-s2.0-85077557678
dc.identifier.scopusqualityQ4
dc.identifier.startpage547
dc.identifier.urihttps://doi.org/10.1134/S1062359019060050
dc.identifier.urihttps://hdl.handle.net/11480/14479
dc.identifier.volume46
dc.identifier.wosWOS:000511334100005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherPleiades Publishing Inc
dc.relation.ispartofBiology Bulletin
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241106
dc.subjectNrf2
dc.subjectKeap1
dc.subjectgenetic variations
dc.subjectcancer resistance
dc.subjectblind mole rat
dc.subjectNannospalax
dc.titleGenetic Variations in Nrf2-Keap1 Complex: A Step towards Understanding Cancer Resistance in Blind Mole Rats Cytotypes
dc.typeArticle

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