The efficacy of autologous serum eye drops for severe dry eye syndrome: A randomized double-blind crossover study

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dc.contributor.authorCelebi A.R.C.
dc.contributor.authorUlusoy C.
dc.contributor.authorMirza G.E.
dc.date.accessioned2019-08-01T13:38:39Z
dc.date.available2019-08-01T13:38:39Z
dc.date.issued2014
dc.departmentNiğde ÖHÜ
dc.description.abstractBackground: To evaluate the efficacy of autologous serum (AS) eye drops for the symptomatic relief of severe dry eye syndrome (DES), as compared to conventional preservative-free artificial tears (PFAT). Methods: This prospective double-blind randomized crossover study used the Ocular Surface Disease Index (OSDI), tear film break-up time (TBUT), Schirmer's Test, and OXFORD Scale at baseline and after each of two 1-month treatment periods to measure the effect of 20 % diluted AS eye drops vs. PFAT in 20 consecutive severe DES patients that were refractory to conventional treatment. Results: The study included 20 (18 female and two male) severe DES patients (40 eyes). Significantly higher TBUT (P?<?0.001, Wilcoxon signed-rank test) and a greater decrease in OSDI score (55.18 % decrease in the AS treatment group vs. 19.50 % decrease in the PFAT treatment group) (P?<?0.001, Student's paired samples t-test) were observed in the AS treatment group after 1 month of treatment. There wasn't a significant difference in Schirmer's test and OXFORD conjunctival and corneal vital dying grading scores between the two treatment groups after 1 month of treatment (P?>?0.05 [Mann-Whitney U test]). Conclusions: AS eye drops were more effective than conventional eye drops for improving tear film stability and subjective comfort in patients with severe DES. © 2014 Springer-Verlag Berlin Heidelberg.
dc.identifier.doi10.1007/s00417-014-2599-1
dc.identifier.endpage626
dc.identifier.issn0721832X
dc.identifier.issue4
dc.identifier.pmid24566903
dc.identifier.startpage619
dc.identifier.urihttps://dx.doi.org/10.1007/s00417-014-2599-1
dc.identifier.urihttps://hdl.handle.net/11480/747
dc.identifier.volume252
dc.indekslendigikaynakPubMed
dc.institutionauthor[0-Belirlenecek]
dc.language.isoen
dc.publisherSpringer Verlag
dc.relation.ispartofGraefe's Archive for Clinical and Experimental Ophthalmology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAutologous serum
dc.subjectDry eye syndrome
dc.subjectOSDI
dc.subjectPreservative-free artificial tears
dc.subjectTBUT
dc.titleThe efficacy of autologous serum eye drops for severe dry eye syndrome: A randomized double-blind crossover study
dc.typeArticle

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