The efficacy of autologous serum eye drops for severe dry eye syndrome: A randomized double-blind crossover study
dc.contributor.author | Celebi A.R.C. | |
dc.contributor.author | Ulusoy C. | |
dc.contributor.author | Mirza G.E. | |
dc.date.accessioned | 2019-08-01T13:38:39Z | |
dc.date.available | 2019-08-01T13:38:39Z | |
dc.date.issued | 2014 | |
dc.department | Niğde ÖHÜ | |
dc.description.abstract | Background: To evaluate the efficacy of autologous serum (AS) eye drops for the symptomatic relief of severe dry eye syndrome (DES), as compared to conventional preservative-free artificial tears (PFAT). Methods: This prospective double-blind randomized crossover study used the Ocular Surface Disease Index (OSDI), tear film break-up time (TBUT), Schirmer's Test, and OXFORD Scale at baseline and after each of two 1-month treatment periods to measure the effect of 20 % diluted AS eye drops vs. PFAT in 20 consecutive severe DES patients that were refractory to conventional treatment. Results: The study included 20 (18 female and two male) severe DES patients (40 eyes). Significantly higher TBUT (P?<?0.001, Wilcoxon signed-rank test) and a greater decrease in OSDI score (55.18 % decrease in the AS treatment group vs. 19.50 % decrease in the PFAT treatment group) (P?<?0.001, Student's paired samples t-test) were observed in the AS treatment group after 1 month of treatment. There wasn't a significant difference in Schirmer's test and OXFORD conjunctival and corneal vital dying grading scores between the two treatment groups after 1 month of treatment (P?>?0.05 [Mann-Whitney U test]). Conclusions: AS eye drops were more effective than conventional eye drops for improving tear film stability and subjective comfort in patients with severe DES. © 2014 Springer-Verlag Berlin Heidelberg. | |
dc.identifier.doi | 10.1007/s00417-014-2599-1 | |
dc.identifier.endpage | 626 | |
dc.identifier.issn | 0721832X | |
dc.identifier.issue | 4 | |
dc.identifier.pmid | 24566903 | |
dc.identifier.startpage | 619 | |
dc.identifier.uri | https://dx.doi.org/10.1007/s00417-014-2599-1 | |
dc.identifier.uri | https://hdl.handle.net/11480/747 | |
dc.identifier.volume | 252 | |
dc.indekslendigikaynak | PubMed | |
dc.institutionauthor | [0-Belirlenecek] | |
dc.language.iso | en | |
dc.publisher | Springer Verlag | |
dc.relation.ispartof | Graefe's Archive for Clinical and Experimental Ophthalmology | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.subject | Autologous serum | |
dc.subject | Dry eye syndrome | |
dc.subject | OSDI | |
dc.subject | Preservative-free artificial tears | |
dc.subject | TBUT | |
dc.title | The efficacy of autologous serum eye drops for severe dry eye syndrome: A randomized double-blind crossover study | |
dc.type | Article |