The interaction of ER stress and autophagy in trophoblasts: navigating pregnancy outcome

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dc.authoridElsabagh, Mabrouk/0000-0002-0596-6547
dc.contributor.authorZheng, Yi
dc.contributor.authorZha, Xia
dc.contributor.authorZhang, Bei
dc.contributor.authorElsabagh, Mabrouk
dc.contributor.authorWang, Hongrong
dc.contributor.authorWang, Mengzhi
dc.contributor.authorZhang, Hao
dc.date.accessioned2024-11-07T13:35:05Z
dc.date.available2024-11-07T13:35:05Z
dc.date.issued2024
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractThe endoplasmic reticulum is a complex and dynamic organelle that initiates unfolded protein response and endoplasmic reticulum stress in response to the accumulation of unfolded or misfolded proteins within its lumen. Autophagy is a paramount intracellular degradation system that facilitates the transportation of proteins, cytoplasmic components, and organelles to lysosomes for degradation and recycling. Preeclampsia and intrauterine growth retardation are two common complications of pregnancy associated with abnormal trophoblast differentiation and placental dysfunctions and have a major impact on fetal development and maternal health. The intricate interplay between endoplasmic reticulum stress, and autophagy and their impact on pregnancy outcomes, through mediating trophoblast differentiation and placental development, has been highlighted in various reports. Autophagy controls trophoblast regulation through a variety of gene expressions and signaling pathways while excessive endoplasmic reticulum stress triggers downstream apoptotic signaling, culminating in trophoblast apoptosis. This comprehensive review delves into the intricacies of placental development and explores the underlying mechanisms of preeclampsia and intrauterine growth retardation. In addition, this review will elucidate the molecular mechanisms of endoplasmic reticulum stress and autophagy, both individually and in their interplay, in mediating placental development and trophoblast differentiation, particularly highlighting their roles in preeclampsia and intrauterine growth retardation development. This research seeks to the interplay between endoplasmic reticulum stress and impaired autophagy in the placental trophoderm, offering novel insights into their contribution to pregnancy complications. [GRAPHICS] .
dc.description.sponsorshipProject of National Key Research and Development Program of China [2023YFD1301705]; Cyanine Project of Yangzhou University; Top Talents Award Plan of Yangzhou University
dc.description.sponsorshipThe research was supported by the Project of National Key Research and Development Program of China (2023YFD1301705), the Cyanine Project of Yangzhou University (2020), and the Top Talents Award Plan of Yangzhou University (2020).
dc.identifier.doi10.1093/biolre/ioae066
dc.identifier.endpage311
dc.identifier.issn0006-3363
dc.identifier.issn1529-7268
dc.identifier.issue2
dc.identifier.pmid38678504
dc.identifier.scopus2-s2.0-85201438819
dc.identifier.scopusqualityQ1
dc.identifier.startpage292
dc.identifier.urihttps://doi.org/10.1093/biolre/ioae066
dc.identifier.urihttps://hdl.handle.net/11480/16329
dc.identifier.volume111
dc.identifier.wosWOS:001226214600001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherOxford Univ Press Inc
dc.relation.ispartofBiology of Reproduction
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241106
dc.subjectendoplasmic reticulum stress
dc.subjectautophagy
dc.subjecttrophoblast
dc.subjectpreeclampsia
dc.subjectintrauterine growth retardation
dc.titleThe interaction of ER stress and autophagy in trophoblasts: navigating pregnancy outcome
dc.typeReview Article

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