Hepatoprotective effects of crocin on biochemical and histopathological alterations following acrylamide-induced liver injury in Wistar rats

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dc.contributor.authorGedik S.
dc.contributor.authorErdemli M.E.
dc.contributor.authorGul M.
dc.contributor.authorYigitcan B.
dc.contributor.authorGozukara Bag H.
dc.contributor.authorAksungur Z.
dc.contributor.authorAltinoz E.
dc.date.accessioned2019-08-01T13:38:39Z
dc.date.available2019-08-01T13:38:39Z
dc.date.issued2017
dc.departmentNiğde ÖHÜ
dc.description.abstractThe objective of the present study is the treatment of oxidative damage caused by acrylamide induced oxidative stress in rats with the administration of a strong antioxidant, namely crocin. High acrylamide (AA) levels have genotoxic, carcinogenic and neurotoxic effects on living organisms. In the present study, 40 Wistar rats were randomly divided into four equal groups. These groups were control, acrylamide (25 mg/kg), crocin (50 mg/kg), acrylamide + crocin (25 mg/kg acrylamide and 50 mg/kg crocin) groups. At the end of the application, biochemical and histological variations were examined in liver and blood samples. It was observed that acrylamide administration significantly decreased liver GSH and TAS levels when compared to the control group. On the contrary, it was also observed that AST, ALT, ALP, SOD and CAT activities and TOS and MDA levels increased as a result of acrylamide administration. Histopathological examinations demonstrated inflammatory cell infiltration, hepatocellular necrosis and hemorrhage areas in AA group liver sections. Furthermore, intracytoplasmic vacuolization was detected in hepatocytes. After crocin treatment, it was observed that GSH and TAS levels increased while AST, ALT, ALP, SOD and CAT activities and TOS and MDA levels decreased. Significant decreases were observed in inflammatory cell infiltration and vascular congestion in liver sections and intracytoplasmic vacuolization in hepatocytes after the crocin treatment, while no hepatocellular necrosis and hemorrhages were observed. In the present study, it was demonstrated that crocin treatment removed acrylamide induced liver damage due to the strong antioxidant properties of crocin. © 2017 Elsevier Masson SAS
dc.description.sponsorshipThe present study was sponsored by Karabuk University Scientific Research Fund ( KBU-BAP-15/2-YL-010 )
dc.identifier.doi10.1016/j.biopha.2017.08.139
dc.identifier.endpage770
dc.identifier.issn0753-3322
dc.identifier.pmid28892787
dc.identifier.scopus2-s2.0-85028918484
dc.identifier.scopusqualityQ1
dc.identifier.startpage764
dc.identifier.urihttps://dx.doi.org/10.1016/j.biopha.2017.08.139
dc.identifier.urihttps://hdl.handle.net/11480/1774
dc.identifier.volume95
dc.identifier.wosWOS:000417744400089
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor[0-Belirlenecek]
dc.language.isoen
dc.publisherElsevier Masson SAS
dc.relation.ispartofBiomedicine and Pharmacotherapy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAcrylamide
dc.subjectCrocin
dc.subjectHepatotoxicity
dc.subjectOxidative stress
dc.titleHepatoprotective effects of crocin on biochemical and histopathological alterations following acrylamide-induced liver injury in Wistar rats
dc.typeArticle

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