Significant association of the MDM2 T309G polymorphism with breast cancer risk in a Turkish population

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dc.contributor.authorYilmaz, Meral
dc.contributor.authorTas, Ayca
dc.contributor.authorDonmez, Gonca
dc.contributor.authorKacan, Turgut
dc.contributor.authorSilig, Yavuz
dc.date.accessioned2024-11-07T10:40:01Z
dc.date.available2024-11-07T10:40:01Z
dc.date.issued2018
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractBackground: Breast cancer is a leading cause of death in women worldwide. Genetic polymorphisms have been reported to be important etiological factors. Murine double minute 2 (MDM2) T309G interacts with p53 and mutations in p53 are present in approximately 50% of all cancers. However, it has been reported that effect of the polymorphism on breast cancer risk may vary in different populations. Here, we therefore investigated whether there is an association between MDM2 T309G (rs2279744) polymorphism and breast cancer in a Turkish population. Materials and Methods: We analysed 110 patients with breast cancer and 138 matched? controls. For genotyping, polymerase chain reaction and restriction length fragment polymorphism methods were used. Results: A significant difference was observed between case and control groups with regard to the distribution of the MDM2 T309G polymorphism (p < 0.05). There was a significantly higher frequency of the TT genotype in the control group (p=0.028; OR, 2.42; 95% CI, 1.09-5.37). However, we did not find any relationships among tumor grade and metastasis status and this polymorphism. Conclusion: This study indicates that the MDM2 T309G polymorphism GG genotype and the TG+GG combination may be risk factors for breast cancer in our Turkish population. © 2017, Asian Pacific Organization for Cancer Prevention.
dc.identifier.doi10.22034/APJCP.2018.19.4.1059
dc.identifier.endpage1062
dc.identifier.issn1513-7368
dc.identifier.issue4
dc.identifier.pmid29699057
dc.identifier.scopus2-s2.0-85045856931
dc.identifier.scopusqualityQ3
dc.identifier.startpage1059
dc.identifier.urihttps://doi.org/10.22034/APJCP.2018.19.4.1059
dc.identifier.urihttps://hdl.handle.net/11480/11350
dc.identifier.volume19
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAsian Pacific Organization for Cancer Prevention
dc.relation.ispartofAsian Pacific Journal of Cancer Prevention
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241106
dc.subjectBreast cancer
dc.subjectMDM2 T309G
dc.subjectMurine double minute 2
dc.subjectPolymorphism
dc.titleSignificant association of the MDM2 T309G polymorphism with breast cancer risk in a Turkish population
dc.typeArticle

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