Economic growth leads to increase of obesity and associated hepatocellular carcinoma in developing countries

Basit Öğe Kaydı
dc.authorid0000-0002-4217-9075
dc.authorid0000-0001-9317-0719
dc.authorid0000-0001-9745-8875
dc.authorid0000-0001-6069-7899
dc.contributor.authorSeydel, G. Seyda
dc.contributor.authorKucukoglu, Ozlem
dc.contributor.authorAltinbas, Akif
dc.contributor.authorDemir, O. Oguz
dc.contributor.authorYilmaz, Sezai
dc.contributor.authorAkkiz, Hikmet
dc.contributor.authorCanbay, Ali
dc.date.accessioned2019-08-01T13:38:39Z
dc.date.available2019-08-01T13:38:39Z
dc.date.issued2016
dc.departmentNiğde ÖHÜ
dc.description.abstractHepatocellular carcinoma (HCC) is the most common type of primary liver cancer and the third leading cause of cancer related death worldwide. In recent years, the prevalence of HCC has increased in both developing and developed countries. Most HCC cases develop in the presence of advanced chronic liver disease related to viral hepatitis. In particular hepatitis B virus and hepatitis C virus infections are considered as major HCC risk factors worldwide. However, current studies provide strong evidence for increasing numbers of HCC in nonalcoholic fatty liver disease (NAFLD). NAFLD represents the hepatic manifestation of metabolic syndrome which is based on obesity and insulin resistance. Epidemiologic data clearly demonstrates that NAFLD and obesity-related disorders are significant risk factors for tumor development in general and HCC in particular. As a consequence of life style changes towards higher calorie intake and less exercise, obesity and metabolic syndrome are spreading all over the world. Due to this increase in obesity and metabolic syndrome NAFLD-related HCC will become a major health care problem in the future. In conclusion, better understanding of the impact of NAFLD and obesity in the development of HCC will improve our treatment strategies of HCC and allow preventive measures.
dc.description.sponsorshipWilhelm Laupitz Foundation; TUBITAK-2219 Post-doc research scholarship program
dc.description.sponsorshipSupported by the Wilhelm Laupitz Foundation (A.C.) and by the TUBITAK-2219 Post-doc research scholarship program (A.A.).
dc.identifier.doi10.5604/16652681.1212316
dc.identifier.endpage672
dc.identifier.issn1665-2681
dc.identifier.issue5
dc.identifier.pmid27493104
dc.identifier.scopus2-s2.0-84982952592
dc.identifier.scopusqualityQ2
dc.identifier.startpage662
dc.identifier.urihttps://dx.doi.org/10.5604/16652681.1212316
dc.identifier.urihttps://hdl.handle.net/11480/3584
dc.identifier.volume15
dc.identifier.wosWOS:000397061200001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor[0-Belirlenecek]
dc.language.isoen
dc.publisherMEXICAN ASSOC HEPATOLOGY
dc.relation.ispartofANNALS OF HEPATOLOGY
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectNonalcoholic fatty liver disease
dc.subjectMetabolic syndrome
dc.subjectEpidemiology
dc.titleEconomic growth leads to increase of obesity and associated hepatocellular carcinoma in developing countries
dc.typeReview Article

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