Thymoquinone is protective against 2,3,7,8-tetrachlorodibenzo-p-dioxin induced hepatotoxicity

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dc.contributor.authorErdemli M.E.
dc.contributor.authorYigitcan B.
dc.contributor.authorGul M.
dc.contributor.authorBag H.G.
dc.contributor.authorGul S.
dc.contributor.authorAksungur Z.
dc.date.accessioned2019-08-01T13:38:39Z
dc.date.available2019-08-01T13:38:39Z
dc.date.issued2018
dc.departmentNiğde ÖHÜ
dc.description.abstractWe investigated changes in rat liver tissues following administration of thymoquinone (TQ) against 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induced hepatotoxicity. Fifty rats were assigned randomly to five groups of 10 as follows: control, corn oil, TCDD, TQ and TCDD + TQ. Biochemical and histopathological analyses were conducted on liver tissue. We found that 30 day TCDD administration caused histopathological changes in liver including thickening of Glisson’s capsule, intracytoplasmic vacuolization in hepatocytes, sinusoidal dilation, vascular and sinusoidal congestion and inflammatory cell infiltration. TCDD administration increased malondialdehyde (MDA), total oxidant status (TOS), alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) levels in rat liver tissue and reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) and total antioxidant status (TAS) levels compared to all other groups. In the TQ treated group, GSH, SOD, CAT and TAS levels increased compared to all other groups. MDA, TOS, ALT, AST, ALP levels decreased compared to all other groups. Our histological findings were consistent with the biochemical findings. The oxidative and histologic effects of TCDD were eliminated by TQ treatment. TCDD administration caused oxidative stress in rat liver and TQ administered with TCDD prevented TCDD induced hepatotoxicity. TQ could be considered an alternative anti-TCDD toxicity agent. © 2018, © 2018 The Biological Stain Commission.
dc.identifier.doi10.1080/10520295.2018.1453549
dc.identifier.endpage462
dc.identifier.issn1052-0295
dc.identifier.issue6
dc.identifier.pmid29701106
dc.identifier.scopus2-s2.0-85046014435
dc.identifier.scopusqualityQ2
dc.identifier.startpage453
dc.identifier.urihttps://dx.doi.org/10.1080/10520295.2018.1453549
dc.identifier.urihttps://hdl.handle.net/11480/1619
dc.identifier.volume93
dc.identifier.wosWOS:000447625300007
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor[0-Belirlenecek]
dc.language.isoen
dc.publisherTaylor and Francis Ltd
dc.relation.ispartofBiotechnic and Histochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subject2
dc.subject3
dc.subject7
dc.subject8-tetrachlorodibenzo-p-dioxin
dc.subjecthepatotoxicity
dc.subjectliver
dc.subjectoxidative stress
dc.subjectthymoquinone
dc.titleThymoquinone is protective against 2,3,7,8-tetrachlorodibenzo-p-dioxin induced hepatotoxicity
dc.typeArticle

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