Promising the potential of ?-caryophyllene on mercury chloride-induced alteration in cerebellum and spinal cord of young Wistar albino rats

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dc.contributor.authorYahyazadeh, Ahmad
dc.contributor.authorGur, Fatih Mehmet
dc.date.accessioned2024-11-07T13:32:30Z
dc.date.available2024-11-07T13:32:30Z
dc.date.issued2024
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractMercury chloride (ME) is a chemical pollutant commonly found in the environment, which can contribute to undesirable health consequence worldwide. The current study investigated the detrimental impact of ME on the cerebellum and spinal cord tissues in 6-8-week-old female rats. We also evaluated the neuroprotective efficacy of beta-caryophyllene (BC) against spinal and cerebellar changes caused by ME. Thirty-five young Wistar albino rats were randomly chosen and assigned into five groups: control (CO), olive oil (OI), ME, BC, ME + BC. All samples were analysed by means of unbiased stereological, biochemical, immunohistochemical, and histopathological methods. Our biochemical findings showed that SOD level was significantly increased in the ME group compared to the CO group (p < 0.05). We additionally detected a statistically significant decrease in the number of cerebellar Purkinje cells and granular cells, as well as spinal motor neuron in the ME group compared to the CO group (p < 0.05). In the ME + BC group, the number of Purkinje cells, granular cells, and spinal motor neurons was significantly higher compared to the ME group (p < 0.05). Decreased SOD activity in the ME + BC group was also detected than the ME group (p < 0.05). Immunohistochemical (the tumour necrosis factor-alpha (TNF-alpha)) and histopathological examinations also exhibited crucial information in each of the group. Taken together, ME exposure was associated with neurotoxicity in the cerebellum and spinal cord tissues. BC treatment also mitigated ME-induced neurological alteration, which may imply its potential therapeutic benefits.
dc.description.sponsorshipThe research was supported by Karabuk University Scientific Research Fund
dc.description.sponsorshipNo Statement Available
dc.identifier.doi10.1007/s00210-024-03268-4
dc.identifier.issn0028-1298
dc.identifier.issn1432-1912
dc.identifier.pmid38995373
dc.identifier.scopus2-s2.0-85198407436
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1007/s00210-024-03268-4
dc.identifier.urihttps://hdl.handle.net/11480/15453
dc.identifier.wosWOS:001271546400001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofNaunyn-Schmiedebergs Archives of Pharmacology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectCerebellum
dc.subjectbeta-Caryophyllene
dc.subjectImmunohistochemistry
dc.subjectMercury chloride
dc.subjectRat
dc.subjectSpinal cord
dc.titlePromising the potential of ?-caryophyllene on mercury chloride-induced alteration in cerebellum and spinal cord of young Wistar albino rats
dc.typeArticle

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