Distribution of Aquaporin-4 channels in hippocampus and prefrontal cortex in mk-801-treated balb/c mice

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dc.authoridDonmez Kutlu, Meltem/0000-0002-6151-0579
dc.contributor.authorEricek, Omer Burak
dc.contributor.authorAkillioglu, Kubra
dc.contributor.authorSaker, Dilek
dc.contributor.authorCevik, Ibrahim
dc.contributor.authorKutlu, Meltem Donmez
dc.contributor.authorKara, Samet
dc.contributor.authorYilmaz, Dervis Mansuri
dc.date.accessioned2024-11-07T13:31:33Z
dc.date.available2024-11-07T13:31:33Z
dc.date.issued2022
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractFunctional disorders of the glymphatic system and Aquaporin-4 (AQP-4) channels take part in the pathophysiology of neurodegenerative disease. The aim of this study was to describe the distribution of AQP-4 channels in the prefrontal cortex and hippocampus in a mouse model of NMDA receptor blocking agent-induced schizophrenia-like behavior model. NMDA receptor antagonist MK-801 was used to produce the experimental schizophrenia model. MK-801 injections were administered for eleven days to Balb/c mice intraperitoneally. Beginning from the sixth day of injection, the spatial learning and memory of the mice were tested by the Morris water maze (MWM) task. A group of mice was injected with MK-801 for ten days without the MWM task. Hippocampus and prefrontal specimens were collected from this group. Tissue samples were stained immunohistochemically and AQP-4 channels were examined by electron microscope. Time to find the platform was significantly longer at MK-801 injected group than the control group at the MWM task. Also, time spent at the target quadrant by the MK-801 group was shorter compared to the control group. AQP-4 expression increased significantly at MK-801 group glial cells, neuronal perikaryon, perineuronal and pericapillary spaces. In the MK-801 group, there was remarkable damage in neurons and glial cells. Increased AQP-4 channel expression and neurodegeneration at the MK-801 group induced with schizophrenia-like behavior model. MK-801 induced NMDA receptor blockade causes a decline in cognitive and memory functions. Increased AQP-4 expression at the prefrontal cortex and hippocampus to elicit and transport products of synaptic neurotransmitters and end metabolites is suggested.
dc.description.sponsorshipScientific Research Office of Cukurova University [I.U BAP] [TTU-2018-11154]
dc.description.sponsorshipThis work was supported by the Scientific Research Office of Cukurova University [I.U BAP, Project number: TTU-2018-11154].
dc.identifier.doi10.1080/01913123.2021.2024633
dc.identifier.endpage79
dc.identifier.issn0191-3123
dc.identifier.issn1521-0758
dc.identifier.issue1
dc.identifier.pmid35014582
dc.identifier.scopus2-s2.0-85122738761
dc.identifier.scopusqualityQ3
dc.identifier.startpage63
dc.identifier.urihttps://doi.org/10.1080/01913123.2021.2024633
dc.identifier.urihttps://hdl.handle.net/11480/14913
dc.identifier.volume46
dc.identifier.wosWOS:000741278900001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Inc
dc.relation.ispartofUltrastructural Pathology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241106
dc.subjectAquaporin-4
dc.subjectN-methyl-D-aspartate
dc.subjectschizophrenia
dc.subjectlearning-memory
dc.titleDistribution of Aquaporin-4 channels in hippocampus and prefrontal cortex in mk-801-treated balb/c mice
dc.typeArticle

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