Osthole: A Multifunctional Natural Compound with Potential Anticancer, Antioxidant and Anti-inflammatory Activities

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dc.authoridShafiq, Dr. Nusrat/0000-0002-3270-4227
dc.authoridShah, Muhammad Ajmal/0000-0003-3471-184X
dc.authoridSelamoglu, Zeliha/0000-0001-9056-6435
dc.authoridRiaz, Ammara/0000-0001-5025-9182
dc.contributor.authorZafar, Saba
dc.contributor.authorSarfraz, Iqra
dc.contributor.authorRasul, Azhar
dc.contributor.authorShah, Muhammad Ajmal
dc.contributor.authorHussain, Ghulam
dc.contributor.authorZahoor, Muhammad Kashif
dc.contributor.authorShafiq, Nusrat
dc.date.accessioned2024-11-07T13:34:50Z
dc.date.available2024-11-07T13:34:50Z
dc.date.issued2021
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractNature has always proved to be a significant reservoir of bioactive scaffolds that have been used for the discovery of drugs since times. Medicinal plants continue to be a solid niche for biologi-cally active and therapeutically effective chemical entities, opening up new avenues for the successful treatment of several human diseases. The contribution of plant-derived compounds to drug discovery, either in their original or in the semi-synthetic derivative form, extends far back in time. This review aims to focus on the sources, biological, and pharmacological profile of a pharmacologically active plant-derived coumarin, osthole, which is an important component of numerous remedial plants such as Cnidium monnieri. Several studies have revealed that osthole possess pharmacological properties such as anticancer, antioxidant, anti-hyperglycemic, neuroprotective, and antiplatelet. Osthole has been reported to regulate various signaling pathways, which in turn modulate several apoptosis-related pro-teins, cell cycle regulators, protein kinases, transcriptional factors, cytokines, and growth receptors affiliated with inflammation, proliferation and several other ailments. Osthole is known to halt prolif-eration and metastasis of cancerous cells by arresting the cell cycle and inducing apoptosis. The data in this review paper supports the pharmacological potential of osthole but further experimentation, biosafety profiling and synergistic effects of this compound need to be focused by the researchers to understand the full spectrum of pharmacological potential of this therapeutically potent compound.
dc.description.sponsorshipNagai Foundation Tokyo, Japan; TWASCOMSTECH Research Grant [_17-180 RG/PHA/AS_C]; NRPU [8381/Punjab/NRPU/RD/HEC/2017, 8382/Punjab/NRPU/RD/HEC/2017]
dc.description.sponsorshipWe acknowledge the research grant from The Nagai Foundation Tokyo, Japan (NFT-R-2018), TWASCOMSTECH Research Grant (No._17-180 RG/PHA/AS_C) and NRPU Research Grants (8381/Punjab/NRPU/R&D/HEC/2017, 8382/Punjab/NRPU/R&D/HEC/2017). Moreover, we are highly obliged to HEC Pakistan, for providing access to e-journals related to our study.
dc.identifier.doi10.2174/1389557520666200709175948
dc.identifier.endpage2771
dc.identifier.issn1389-5575
dc.identifier.issn1875-5607
dc.identifier.issue18
dc.identifier.pmid32646359
dc.identifier.scopus2-s2.0-85120085501
dc.identifier.scopusqualityQ2
dc.identifier.startpage2755
dc.identifier.urihttps://doi.org/10.2174/1389557520666200709175948
dc.identifier.urihttps://hdl.handle.net/11480/16197
dc.identifier.volume21
dc.identifier.wosWOS:000710686300001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBentham Science Publ Ltd
dc.relation.ispartofMini-Reviews in Medicinal Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectOsthole
dc.subjectanti-inflammatory
dc.subjectantioxidant
dc.subjectanticancer
dc.subjectanti-diabetic
dc.subjectneuroprotective
dc.titleOsthole: A Multifunctional Natural Compound with Potential Anticancer, Antioxidant and Anti-inflammatory Activities
dc.typeReview Article

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