Effects of propolis on blood biochemical and hematological parameters in nitric oxide synthase inhibited rats by N omega-Nitro-L-arginine methyl ester

Basit Öğe Kaydı
dc.contributor.authorTalas, Zeliha Selamoglu
dc.contributor.authorGogebakan, Ayse
dc.contributor.authorOrun, Ibrahim
dc.date.accessioned2019-08-01T13:38:39Z
dc.date.available2019-08-01T13:38:39Z
dc.date.issued2013
dc.departmentNiğde ÖHÜ
dc.description.abstractThis study showed the effects of propolis on biochemical and hematological parameters in chronic nitric oxide synthase inhibited rats by N-omega-Nitro-L-arginine methyl ester (L-NAME). Rats are given L-NAME for 15 days and the propolis for the last 5 days with L-NAME together. The levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and gamma glutamyltransferase in the L-NAME group compared to control group have increased (P<0.05). The levels of these parameters in L-NAME+propolis group compared to the L-NAME group have decreased (P<0.05). L-NAME caused increase (P<0.05) in levels of glucose, albumin, globulin, creatinine, urea, triglyceride and cholesterol. Erythrocyte number, total leukocyte, hemoglobin, hematocrit, neutrophil and monocyte decreased (P<0.05), platelets and lymphocyte increased (P<0.05) in L-NAME+propolis group compared to the L-NAME group. The study concluded that homeostasis is modulated in L-NAME administrated rats by adding propolis which causes increasing generation of vascular nitric oxide.
dc.description.sponsorshipNigde University Research Fund [FEB 2008/25]
dc.description.sponsorshipNigde University Research Fund (FEB 2008/25) is gratefully acknowledged for support of this work. Thanks for his help to Dr. Engin Sahna at Firat University in Turkey about animal research.
dc.identifier.endpage919
dc.identifier.issn1011-601X
dc.identifier.issue5
dc.identifier.pmid24035946
dc.identifier.startpage915
dc.identifier.urihttps://hdl.handle.net/11480/4359
dc.identifier.volume26
dc.identifier.wosWOS:000325830800009
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.institutionauthor[0-Belirlenecek]
dc.language.isoen
dc.publisherUNIV KARACHI
dc.relation.ispartofPAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBiochemical parameter
dc.subjectblood
dc.subjecthematological parameter
dc.subjectL-NAME
dc.subjectpropolis
dc.subjectrat
dc.titleEffects of propolis on blood biochemical and hematological parameters in nitric oxide synthase inhibited rats by N omega-Nitro-L-arginine methyl ester
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu