Effects of propolis on blood biochemical and hematological parameters in nitric oxide synthase inhibited rats by N omega-Nitro-L-arginine methyl ester
dc.contributor.author | Talas, Zeliha Selamoglu | |
dc.contributor.author | Gogebakan, Ayse | |
dc.contributor.author | Orun, Ibrahim | |
dc.date.accessioned | 2019-08-01T13:38:39Z | |
dc.date.available | 2019-08-01T13:38:39Z | |
dc.date.issued | 2013 | |
dc.department | Niğde ÖHÜ | |
dc.description.abstract | This study showed the effects of propolis on biochemical and hematological parameters in chronic nitric oxide synthase inhibited rats by N-omega-Nitro-L-arginine methyl ester (L-NAME). Rats are given L-NAME for 15 days and the propolis for the last 5 days with L-NAME together. The levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and gamma glutamyltransferase in the L-NAME group compared to control group have increased (P<0.05). The levels of these parameters in L-NAME+propolis group compared to the L-NAME group have decreased (P<0.05). L-NAME caused increase (P<0.05) in levels of glucose, albumin, globulin, creatinine, urea, triglyceride and cholesterol. Erythrocyte number, total leukocyte, hemoglobin, hematocrit, neutrophil and monocyte decreased (P<0.05), platelets and lymphocyte increased (P<0.05) in L-NAME+propolis group compared to the L-NAME group. The study concluded that homeostasis is modulated in L-NAME administrated rats by adding propolis which causes increasing generation of vascular nitric oxide. | |
dc.description.sponsorship | Nigde University Research Fund [FEB 2008/25] | |
dc.description.sponsorship | Nigde University Research Fund (FEB 2008/25) is gratefully acknowledged for support of this work. Thanks for his help to Dr. Engin Sahna at Firat University in Turkey about animal research. | |
dc.identifier.endpage | 919 | |
dc.identifier.issn | 1011-601X | |
dc.identifier.issue | 5 | |
dc.identifier.pmid | 24035946 | |
dc.identifier.startpage | 915 | |
dc.identifier.uri | https://hdl.handle.net/11480/4359 | |
dc.identifier.volume | 26 | |
dc.identifier.wos | WOS:000325830800009 | |
dc.identifier.wosquality | Q4 | |
dc.indekslendigikaynak | Web of Science | |
dc.indekslendigikaynak | PubMed | |
dc.institutionauthor | [0-Belirlenecek] | |
dc.language.iso | en | |
dc.publisher | UNIV KARACHI | |
dc.relation.ispartof | PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.subject | Biochemical parameter | |
dc.subject | blood | |
dc.subject | hematological parameter | |
dc.subject | L-NAME | |
dc.subject | propolis | |
dc.subject | rat | |
dc.title | Effects of propolis on blood biochemical and hematological parameters in nitric oxide synthase inhibited rats by N omega-Nitro-L-arginine methyl ester | |
dc.type | Article |