The Effects on Oxidative Systems in Liver Tissues of Systemic Ozone Application after Critical Size Hone Defect Surgery in Rat Mandibles

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dc.contributor.authorErdemli, Mehmet Erman
dc.contributor.authorAkgul, Hasan
dc.contributor.authorSelamoglu, Zeliha
dc.date.accessioned2024-11-07T13:32:55Z
dc.date.available2024-11-07T13:32:55Z
dc.date.issued2019
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractExamination of the changes that non-toxic doses of antioxidant action ozone used in increasing osteogenic activity by dentists causes on rat liver tissues. The effects of ozone applications that are significant in mandibular bone defect therapies and oral and maxillofacial surgery practice on oxidant / antioxidant system in rat liver tissues are investigated by analyzing malondialdehyde (MDA), reduced glutathione (GSH), superoxide dismutase (SOD), and catalase (CAT) parameters. While there were statistically significant reductions in MDA levels and SOD activities after 15 and 45 days long ozone applications on critical mandibular bone defect induced rat livers, statistically significant increases were observed in GSH levels and CAT activities (P <= 0.05). This is the first study where the effects of ozone therapies used in treatment of mandibular bone defect on liver tissue oxidant / antioxidant system in rats are scrutinized with the analysis of biochemical parameters. It was determined that ozone applications did not have any negative effects on liver tissue oxidant / antioxidant system and concurrently had positive effects on liver antioxidant system and to reveal the biochemical mechanism completely, further studies are needed.
dc.identifier.doi10.25083/rbl/24.3/538.544
dc.identifier.endpage544
dc.identifier.issn1224-5984
dc.identifier.issue3
dc.identifier.startpage538
dc.identifier.urihttps://doi.org/10.25083/rbl/24.3/538.544
dc.identifier.urihttps://hdl.handle.net/11480/15680
dc.identifier.volume24
dc.identifier.wosWOS:000472746500023
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherArs Docendi
dc.relation.ispartofRomanian Biotechnological Letters
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectLiver
dc.subjectmandibular bone defect
dc.subjectoxidative stress
dc.subjectozone
dc.subjectrat
dc.titleThe Effects on Oxidative Systems in Liver Tissues of Systemic Ozone Application after Critical Size Hone Defect Surgery in Rat Mandibles
dc.typeArticle

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