Investigation of TLR2 (-196 to -174del) and TLR9 (T-1486C) Gene Polymorphisms Association with Inflammatory Bowel Diseases

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dc.contributor.authorEmele, Roseline Eke
dc.contributor.authorA.Salim, Mohammed
dc.contributor.authorPolat, Fikriye
dc.contributor.authorDiler, Songül Budak
dc.date.accessioned2024-11-07T10:40:01Z
dc.date.available2024-11-07T10:40:01Z
dc.date.issued2024
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractBackground: Inflammatory bowel diseases (IBD), Crohn’s disease (CD), and ulcerative colitis (UC) are diseases that result from the combined effects of a predisposing genetic background and several environmental factors, including smoking. Some genes can influence these diseases through genetic inheritance, and their regulation is explained by gene polymorphism. However, Toll-like receptor (TLR) genes have been identified as susceptibility genes for CD and UC. Methods: A case-control study was performed on a Turkish population composed of 105 healthy controls and 79 CD, 77 UC patients genotyped by Allele-specific PCR and PCR–RFLP for TLR9 (T-1486C) and TLR 2 (-196 to -174del) gene. Genotype and allele frequencies of TLR9 (T-1486C) and TLR 2 (-196 to -174del) gene polymorphisms compared to allele frequencies in CD and UC patients. Results: No statistically significant findings were found between the CD, UC patients, and the control group in terms of both genotype distributions and allele frequencies for TLR 9 (T-1486C; rs187084) and TLR 2 (-196 to -174del; rs111200466) gene polymorphisms in a Turkish population (P?> 0.05). Conclusion: No association was found between the TLR2 (rs111200466) and TLR 9 (rs187084) gene polymorphisms among IBD patients and the control groups in the Turkish population. © (2024), This work is licensed under a Creative Commons Attribution-Non Commercial 4.0 International License.
dc.description.sponsorshipÖmer Halisdemir Üniversitesi; Institute of Science and Technology Austria, ISTA; Erciyes Üniversitesi
dc.identifier.doi10.31557/APJCP.2024.25.6.2003
dc.identifier.endpage2010
dc.identifier.issn1513-7368
dc.identifier.issue6
dc.identifier.pmid38918662
dc.identifier.scopus2-s2.0-85197086511
dc.identifier.scopusqualityQ3
dc.identifier.startpage2003
dc.identifier.urihttps://doi.org/10.31557/APJCP.2024.25.6.2003
dc.identifier.urihttps://hdl.handle.net/11480/11349
dc.identifier.volume25
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAsian Pacific Organization for Cancer Prevention
dc.relation.ispartofAsian Pacific Journal of Cancer Prevention
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectInflammatory Bowel Diseases
dc.subjectPolymorphism
dc.subjectTLR 2 (–196 to –174del)
dc.subjectTLR 9 (T-1486C)
dc.titleInvestigation of TLR2 (-196 to -174del) and TLR9 (T-1486C) Gene Polymorphisms Association with Inflammatory Bowel Diseases
dc.typeArticle

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