Mild regular treadmill exercise ameliorated the detrimental effects of acute sleep deprivation on spatial memory

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dc.authoridkocahan, sayad/0000-0002-3161-1280
dc.contributor.authorSahin, Leyla
dc.contributor.authorCevik, Ozge Selin
dc.contributor.authorCevik, Kenan
dc.contributor.authorGuven, Celal
dc.contributor.authorTaskin, Eylem
dc.contributor.authorKocahan, Sayad
dc.date.accessioned2024-11-07T13:34:32Z
dc.date.available2024-11-07T13:34:32Z
dc.date.issued2021
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractVulnerable areas like the hippocampus are sensitive to insults such as sleep deprivation (SD); they are also susceptible to environmental enrichment. Much evidence is accumulating that chronic sleep deprivation causes alterations in the hippocampus that responsible for spatial memory. However, there is conflicting about the differences between acute and chronic SD results. The purpose of this study was to determine the protective effects of mild treadmill exercise on acute SD rats. Four groups were created as control, exercise, sleep deprivation, exercise + sleep deprivation. Multiple platforms method was used to induce REM sleep deprivation (RD) for 48 h. The exercise was applied five days per week for four weeks (5 x 4). For the first and second weeks, the length of the exercise was 15 min in two sessions (5 min interval) followed by 15 min in three, 15 min in four sessions. Morris water maze (MWM) was used as a spatial memory test. Gene level was determined by using the qPCR technique. Malondialdehyde (MDA) content in the hippocampus was measured as an extent of peroxidative damage to lipids by using the ELISA method. 48 h RD impaired long-term spatial memory significantly. Mild, regular treadmill exercise ameliorated the detrimental effects of acute sleep deprivation on memory. There was no significant difference in MDA between groups. Hippocampal gene expression did not show any changes in all groups. Lack of correlation between memory impairment and levels of genes in the hippocampus is likely to be related to the differences in behavioral and genetic mechanisms.
dc.identifier.doi10.1016/j.brainres.2021.147367
dc.identifier.issn0006-8993
dc.identifier.issn1872-6240
dc.identifier.pmid33582122
dc.identifier.scopus2-s2.0-85102121104
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.brainres.2021.147367
dc.identifier.urihttps://hdl.handle.net/11480/16037
dc.identifier.volume1759
dc.identifier.wosWOS:000628876800003
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofBrain Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241106
dc.subjectSleep deprivation
dc.subjectMemory
dc.subjectExercise
dc.subjectHippocampus
dc.subjectOxidative stress
dc.titleMild regular treadmill exercise ameliorated the detrimental effects of acute sleep deprivation on spatial memory
dc.typeArticle

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