Histone deacetylase inhibitory properties of metabolites from leaves of Quercus pontica K. Koch and its metabolites

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dc.authoridSohretoglu, Didem/0000-0002-8264-5544
dc.contributor.authorRenda, Gulin
dc.contributor.authorSevgi, Sezer
dc.contributor.authorSoral, Michal
dc.contributor.authorBora-Akoglu, Gamze
dc.contributor.authorSari, Suat
dc.contributor.authorCetin, Ozge
dc.contributor.authorZobaroglu-Ozer, Pelin
dc.date.accessioned2024-11-07T13:35:15Z
dc.date.available2024-11-07T13:35:15Z
dc.date.issued2024
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractThe infusions prepared from some Quercus L. species are used in folk medicine for medicinal purposes and consumed as tea. Quercus pontica K. Koch was selected in this study, for which no phytochemical isolation studies have been performed so far. Quercetin 3-O- beta-D-glucopyranoside, kaempferol 3-O-(6-O-galloyl)-beta-D-glucopyranoside, kaempferol 3-O-beta-D-glucopyranoside, kaempferol 3-O-(6'-coumaroyl-beta-D-glucopyranoside, phlorizin, rosmarinic acid, and catechin were isolated from the titled plant for the first time. Some polyphenolic compounds have been shown to inhibit histone deacetylase (HDAC) enzymes. However, there is no study on the any activities of Quercus species in the literature. In this study, we demonstrated that the extract has in vitro pan-HDAC inhibition activity. Through a virtual screening study, the compounds were found to inhibit HDAC7 more strongly than the other HDAC isoforms; therefore, the HDAC7 inhibition activities were studied in vitro. Kaempferol 3-O-beta-D-glucopyranoside and kaempferol 3-O-(6'-coumaroyl-beta-D-glucopyranoside) showed the best anti-HDAC7 activity with 37% and 41% inhibition at 500 mu M.
dc.description.sponsorshipScientific Research Foundation of Hacettepe University, Turkey [THD-2019-18495]; Scientific Grant Agency of the Slovak Republic VEGA [2/0118/23]; Operational Program Integrated Infrastructure for the project: Development of products by modification of natural substances and study of their multimodal effects on COVID-19 [ITMS: 313011ATT2]; European Regional Development Fund
dc.description.sponsorshipThis research was supported by the Scientific Research Foundation of Hacettepe University, Turkey [Project number THD-2019-18495] and the Scientific Grant Agency of the Slovak Republic VEGA [Project number 2/0118/23]. This publication was created with the support of the Operational Program Integrated Infrastructure for the project: Development of products by modification of natural substances and study of their multimodal effects on COVID-19, ITMS: 313011ATT2, co-financed by the European Regional Development Fund.
dc.identifier.doi10.1080/09603123.2024.2399210
dc.identifier.issn0960-3123
dc.identifier.issn1369-1619
dc.identifier.pmid39234646
dc.identifier.scopus2-s2.0-85203152465
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1080/09603123.2024.2399210
dc.identifier.urihttps://hdl.handle.net/11480/16412
dc.identifier.wosWOS:001307497400001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofInternational Journal of Environmental Health Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241106
dc.subjectHistone deacetylase (HDAC)
dc.subjectkaempferol 3-O-beta-D-glucopyranoside
dc.subjectmolecular modelling
dc.subjectQuercus pontica
dc.titleHistone deacetylase inhibitory properties of metabolites from leaves of Quercus pontica K. Koch and its metabolites
dc.typeArticle

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